Comparison of prognostic gene expression signatures for breast cancer

BMC Genomics

Table 1 Characteristics of patients of the TRANSBIG validation series (n = 198), according to the 70-gene signature (GENE70), the 76-gene signature (GENE76), the Gene expression Grade Index (GGI) and the Adjuvant! Online (AOL) risk classifications.

Signature	GENE70		GENE76		GGI		AOL
Number of patients	Low-risk (N = 66)	High-risk (N = 132)	Low-risk (N = 55)	High-risk (N = 143)	Low-risk (N = 69)	High-risk (N = 129)	Low-risk (N = 46)	High-risk (N = 152)
Age
< 41 years	11	31	10	32	10	32	4	38
41–50 years	33	67	24	76	33	67	33	67
51–60 years	33	34	24	35	26	30	9	47
Size
T1ab (< 1 cm)	4	5	4	5	4	5	8	1
T1c (1–2 cm)	24	35	17	42	25	34	21	38
T2 (2–5 cm)	38	92	34	96	40	90	17	113
Tumor grade
Good differentiation	17	13	14	16	20	10	23	7
Intermediate	42	41	21	62	44	39	23	60
Poor differentiation	7	76	20	63	5	78	0	83
Unknown	0	2	0	2	0	2	0	2
Estrogen receptors
Positive	63	71	41	93	65	69	46	88
Negative	3	61	14	50	4	60	0	64

ISSN: 1471-2164