Table 3 Multivariate Cox analyses for the 70-gene signature (GENE70), the 76-gene signature (GENE76) and the Gene expression Grade Index (GGI) risk classifications.
From: Comparison of prognostic gene expression signatures for breast cancer
| Â | GENE70 | GENE76 | GGI | |||
|---|---|---|---|---|---|---|
| Â | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value |
Age (≤ or >50 years) | 1.51 (0.82–2.79) | 0.3 | 1.78 (0.97–3.25) | 0.062 | 1.73 (0.94–3.16) | 0.077 |
Tumor Size (≤ or >2 cm) | 1.3 (0.72–2.5) | 0.36 | 1.27 (0.68–2.37) | 0.45 | 1.22 (0.65–2.29) | 0.53 |
ER status | 0.82 (0.43–1.6) | 0.57 | 0.6 (0.31–1.17) | 0.13 | 0.78 (0.4–1.51) | 0.46 |
Grade | 0.93 (0.34–2.53) | 0.89 | 1.51 (0.53–4.28) | 0.5 | 0.75 (0.27–2.08) | 0.58 |
Risk according to the gene signature | 7.1 (2.4–21) | 4 × 10-4 | 3.39 (1.41–8.12) | 6 × 10-3 | 6.42 (2.36–17.45) | 3 × 10-4 |