Comparison of methods' sensitivity and specificity. Data refer to the simulation of 500 cases and 500 controls assuming a dominant model. Each panel reports the sensitivity/specificity tradeoff for DIprimeCI (triangle), 4Gamete (reversed triangle), the SSD (diamond), HapBlock (square) and MATILDE (represented by points on the ROC curves, graphed as circles, and a smooth estimate of the ROC curve). In addition an allele-based single-SNP association analysis is represented by an "x" while the genotype-based single-SNP association analysis is represented by a "+". Four effect sizes were considered: the OR is 1.2, 1.4, 1.6 and 1.8, respectively.