Table 1 Estimated STR overrepresentation in disease-related genes, relative to the proportion of STR in reference genes.
From: Short Tandem Repeats in Human Exons: A Target for Disease Mutations
Gene set | #Genes | STR overrepresentation a | P-value |
|---|---|---|---|
Human genes | |||
Reference set | 11210 | - | - |
All diseases | 2095 | 7.0 % [4.6, inf] | 2.1 × 10-7 |
Leukaemia | 70 | 28.3 % [15.2, inf] | 1.7 × 10-4 |
Cancers | 151 | 17.5 % [8.8, inf] | 3.3 × 10-4 |
Immune system diseases | 52 | 16.5 % [3.0, inf] | 2.1 × 10-2 |
Mouse genes | |||
Reference set | 17077 | - | - |
Cancers | 294 | 12.1 % [5.3, inf] | 7.6 × 10-4 |
Postnatal lethality | 764 | 25.7 % [21.6, inf] | <10-12 |