Table 1 List of 138 S. aureus genes that were most strongly affected by OPP and are discussed in this report categorized by their related function. The microarray results are the mean of five replicates of each gene.
From: Microarray analysis of toxicogenomic effects of Ortho-phenylphenol in Staphylococcus aureus
| Â | Â | 20 min | 60 min | Â | Â | Â | ||
|---|---|---|---|---|---|---|---|---|
Affymetrix Probe ID | ORF no. | p-value | Fold change | p-value | Fold change | Description | Gene symbol | Functional class |
Group I: Upregulation (20 min) – Upregulation (60 min) 18 genes | ||||||||
sa_c6812s5946_a_at | SA0265 | 8.55E-06 | 2.1 | 8.55E-06 | 3.1 | peptidoglycan hydrolase (surface antigen) | lyt M | Cell envelope biogenesis, outer membrane |
sa_c7382s10191_a_at | SA0423* | 5.16E-07 | 8.1 | 5.16E-07 | 19.4 | hypothetical protein, similar to autolysin (N-acetylmuramoyl-L-alanine amidase) | Â | General function prediction only |
sa_c7698s6703_a_at | SA0519 | 0.00293 | 2.8 | 0.00293 | 2.5 | Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein | sdr C | Cell envelope biogenesis, outer membrane |
sa_c8045s7032_at | SA0620 | 1.27E-06 | 7.6 | 1.27E-06 | 5.6 | hypothetical protein, similar to secretory antigen precursor SsaA | Â | General function prediction only |
sa_c592s9345_a_at | SA0905 | 4.83E-08 | 5.7 | 4.83E-08 | 7.0 | N-acetylglucosaminidase (major autolysin) | atl | Cell envelope biogenesis, outer membrane |
sa_c1007s793_a_at | SA1003 | 7.81E-06 | 3.7 | 7.81E-06 | 4.2 | fibrinogen-binding protein precursor | Â | hypothetical protein |
sa_c4394s3743_a_at | SA1898 | 7.99E-05 | 6.1 | 7.99E-05 | 5.8 | hypothetical protein, simialr to SceD precursor | Â | hypothetical protein |
sa_c4612s9984cs_s_at | SA1972 | 0.00267 | 2.2 | 0.00267 | 2.7 | multidrug resistance protein (efflux transporter) | Â | hypothetical protein |
sa_c5066s4362_a_at | SA2093* | 0.00025 | 6.8 | 0.00025 | 9.0 | hypothetical protein, similar to secretory antigen precursor SsaA | ssa A | General function prediction only |
sa_c5082s4380_a_at | SA2097* | 3.71E-05 | 6.9 | 3.71E-05 | 11.5 | hypothetical protein, similar to secretory antigen precursor SsaA | Â | General function prediction only |
sa_c342s182_a_at | SA2142 | 9.36E-07 | 3.6 | 9.36E-07 | 3.6 | multidrug resistance protein B (drug efflux transporter) | Â | hypothetical protein |
sa_c5274s4572_a_at | SA2143 | 1.24E-07 | 3.9 | 1.24E-07 | 4.1 | multidrug resistance efflux pump | Â | hypothetical protein |
sa_c5652s4904_a_at | SA2206 | 0.00082 | 2.5 | 0.00082 | 2.8 | Immunoglobulin G binding protein A precursor | sbi | Cell envelope biogenesis, outer membrane |
sa_c6151s5333_a_at | SA2332 | 0.00019 | 7.8 | 0.00019 | 8.6 | hypothetical protein, similar to secretory antigen precursor SsaA | Â | General function prediction only |
sa_c6250s5428_a_at | SA2353* | 1.91E-05 | 10.2 | 1.91E-05 | 13.8 | secretory antigen precursor SsaA homolog | Â | General function prediction only |
sa_c9402s8223_a_at | SA2355* | 3.23E-06 | 8.5 | 3.23E-06 | 9.4 | transcriptional regulator, MARR family | Â | hypothetical protein |
sa_c6259s5439_a_at | SA2356 | 3.43E-06 | 6.5 | 3.43E-06 | 6.9 | immunodominant antigen A | isa A | Cell envelope biogenesis, outer membrane |
sa_c6506s5675_a_at | SA2423 | 0.00148 | 2.9 | 0.00148 | 3.5 | fibrinogen-binding protein A, clumping factor | clf B | Posttranslational modification, protein turnover, chaperones |
Group II: Upregulation (20 min) – No change (60 min) 28 genes | ||||||||
sa_c7511s6531_a_at | SA0459 | 0.000138 | 2.3 | Â | Â | ribosomal protein L25 (general stress protein Ctc) | rpl Y | Translation, ribosomal structure and biogenesis |
sa_c7621s6634_a_at | SA0497 | 7.95E-05 | 2.2 | Â | Â | 50S ribosomal protein L10; ribosomal protein L10 (BL5) | Â | Translation, ribosomal structure and biogenesis |
sa_c7625s6638_at | SA0498 | 5.07E-05 | 3.5 | Â | Â | 50S ribosomal protein L7:L12; ribosomal protein L7:L12 | Â | Translation, ribosomal structure and biogenesis |
sa_c1147s928_a_at | SA1041 | 0.00142 | 2.8 | Â | Â | uracil phosphoribosyltransferase; Pyrimidine operon regulatory protein pyrR | Â | Nucleotide transport and metabolism |
sa_c1151s932_a_at | SA1042 | 0.000143 | 6.7 | Â | Â | uracil permease (uracil transporter) | pyr P | Nucleotide transport and metabolism |
sa_c9991s8687_a_at | SA1043 | 7.66E-05 | 6.5 | Â | Â | aspartate carbamoyltransferase catalytic chain (Aspartate transcarbamylase) (ATCase) | pyr B | Nucleotide transport and metabolism |
sa_c1155s937_a_at | SA1044 | 0.000101 | 6.0 | Â | Â | dihydroorotase, dihydroorotase-like | pry C | Nucleotide transport and metabolism |
sa_c1159s942_a_at | SA1045 | 0.000161 | 5.1 | Â | Â | carbamoyl-phosphate synthase, arginine-specific, small chain | pyr AA | Amino acid transport and metabolism, Nucleotide transport and metabolism |
sa_c1165s946_a_at | SA1046 | 0.00018 | 3.3 | Â | Â | carbamoyl-phosphate synthase, arginine-specific, large chain | car B | Amino acid transport and metabolism, Nucleotide transport and metabolism |
sa_c1167s950_a_at | SA1047 | 0.000788 | 3.3 | Â | Â | orotidine 5-phosphate decarboxylase | pyr F | Nucleotide transport and metabolism |
sa_c9989s8682_a_at | SA1048 | 0.00107 | 3.0 | Â | Â | orotate phosphoribosyltransferase | pyr E | Nucleotide transport and metabolism |
sa_c1302s1077_a_at | SA1084 | 0.000221 | 2.7 | Â | Â | 50S ribosomal protein L19; ribosomal protein L19 | rpl S | Translation, ribosomal structure and biogenesis |
sa_c4792s4098_at | SA2022 | 0.000417 | 2.1 | Â | Â | 50S ribosomal protein L17; ribosomal protein L17 | rpl Q | Translation, ribosomal structure and biogenesis |
sa_c4824s4130_a_at | SA2029 | 2.76E-05 | 2.1 | Â | Â | 50S ribosomal protein L15; ribosomal protein L15 | rpl O | Translation, ribosomal structure and biogenesis |
sa_c4836s4142_at | SA2032 | 0.00024 | 2.1 | Â | Â | 50S ribosomal protein L18; ribosomal protein L18 | rpl R | Translation, ribosomal structure and biogenesis |
sa_c9951s8647_at | SA2033 | 0.000342 | 2.6 | Â | Â | 50S ribosomal protein L6; ribosomal protein L6 (BL8) | rpl F | Translation, ribosomal structure and biogenesis |
sa_c4848s4156_at | SA2035 | 0.0021 | 2.1 | Â | Â | 50S ribosomal protein L5; ribosomal protein L5 (BL6) | rps N | Translation, ribosomal structure and biogenesis |
sa_c4852s4158_at | SA2036 | 0.00267 | 2.1 | Â | Â | 50S ribosomal protein L24; ribosomal protein L24 (BL23) | rpl X | Translation, ribosomal structure and biogenesis |
sa_c10191s8871_a_at | SA2038 | 0.0026 | 2.8 | Â | Â | 30S ribosomal protein S17; ribosomal protein S17 (BS16) | rps Q | Translation, ribosomal structure and biogenesis |
sa_c4860s4166_at | SA2039 | 0.00204 | 2.5 | Â | Â | 50S ribosomal protein L29; ribosomal protein L29 | rpm C | Translation, ribosomal structure and biogenesis |
sa_c4864s4170_at | SA2040 | 0.000749 | 2.7 | Â | Â | 50S ribosomal protein L16; ribosomal protein L16 | rpl P | Translation, ribosomal structure and biogenesis |
sa_c4868s4175_a_at | SA2041 | 0.0024 | 2.8 | Â | Â | 30S ribosomal protein S3; ribosomal protein S3 (BS3) | rps C | Translation, ribosomal structure and biogenesis |
sa_c4876s4184_at | SA2043 | 0.00405 | 2.8 | Â | Â | 30S ribosomal protein S19; ribosomal protein S19 (BS19) | rps S | Translation, ribosomal structure and biogenesis |
sa_c9959s8654_a_at | SA2044 | 0.000888 | 2.5 | Â | Â | 50S ribosomal protein L2; ribosomal protein L2 (BL2) | rpl B | Translation, ribosomal structure and biogenesis |
sa_c10192s8875_a_at | SA2045 | 0.00434 | 2.7 | Â | Â | 50S ribosomal protein L23; ribosomal protein L23 | rpl W | Translation, ribosomal structure and biogenesis |
sa_c4880s4187_at | SA2046 | 0.00283 | 2.8 | Â | Â | 50S ribosomal protein L4; ribosomal protein L4 | rpl D | Translation, ribosomal structure and biogenesis |
sa_c4888s4195_a_at | SA2047 | 0.00069 | 2.3 | Â | Â | 50S ribosomal protein L3; ribosomal protein L3 (BL3) | rpl C | Translation, ribosomal structure and biogenesis |
sa_c9963s8658_a_at | SA2048 | 0.00245 | 2.4 | Â | Â | 30S ribosomal protein S10; ribosomal protein S10 (BS13) | rps J | Translation, ribosomal structure and biogenesis |
Group III: No change (20 min) – Upregulation (60 min) 8 genes | ||||||||
sa_c10571s9056_a_at | SA0845 | Â | Â | 0.000581 | 2.5 | putative oligopeptide ABC transporter integral membrane protein (fragment) | opp B | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c324s166_a_at | SA0846 | Â | Â | 0.00019 | 2.4 | probable peptide ABC transporter permease ABC transporter protein | opp C | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c328s170_a_at | SA0847 | Â | Â | 0.00293 | 2.2 | probable peptide ABC transporter ATP-binding ABC transporter protein | opp D | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c332s172_a_at | SA0848 | Â | Â | 9.13E-05 | 2.2 | probable peptide ABC transporter ATP-binding ABC transporter protein | opp F | Amino acid transport and metabolism |
sa_c5349s4625_a_at | SA0950 |  |  | 0.0022 | 2.2 | ABC transporter ATP-binding protein – spermidine:putrescine transport | pot A | Amino acid transport and metabolism |
sa_c795s596_a_at | SA0952 |  |  | 0.00536 | 2.2 | ABC transporter membrane-spanning permease – spermidine:putrescine transport | pot C | Amino acid transport and metabolism |
sa_c803s604_a_at | SA0953 | Â | Â | 0.00987 | 2.2 | spermidine:putrescine ABC transporter, spermidine: putrescine-binding periplasmic protein (potD) homolog | pot D | Amino acid transport and metabolism |
sa_c8848s7783_a_at | SA1601 | Â | Â | 0.000923 | 2.3 | CRCB, CrcB-like protein | Â | Cell division and chromosome partitioning |
Group IV: Downregulation (20 min) – Downregulation (60 min) 27 genes | ||||||||
sa_c5061s4360_a_at | SA0229 | 4.85E-07 | -5.8 | 4.85E-07 | -4.8 | dipeptide ABC transporter, periplasmic dipeptide-binding protein (dppA) | Â | Amino acid transport and metabolism |
sa_c736s544_a_at | SA0937 | 0.00365 | -2.9 | 0.00365 | -3.5 | cytochrome D ubiquinol oxidase subunit I | Â | Energy production and conversion |
sa_c740s548_a_at | SA0938 | 0.00375 | -2.9 | 0.00375 | -3.4 | cytochrome D ubiquinol oxidase subunit II homolog | Â | Energy production and conversion |
sa_c1659s1395_a_at | SA1164* | 0.000431 | -8.9 | 0.000431 | -3.4 | homoserine dehydrogenase (HDH) | dho M | Amino acid transport and metabolism |
sa_c1665s1401_a_at | SA1165 | 0.00011 | -8.3 | 0.00011 | -3.2 | threonine synthase (EC 4.2.3.1) homolog thrC | thr C | Amino acid transport and metabolism |
sa_c1669s1406_a_at | SA1166 | 5.06E-05 | -11.5 | 5.06E-05 | -3.8 | homoserine kinase (thrB) | thr B | Amino acid transport and metabolism |
sa_c1872s1598_a_at | SA1213 | 0.00127 | -2.8 | 0.00127 | -2.4 | probable peptide ABC transporter permease ABC transporter protein | opp- 2C | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c1876s1602_a_at | SA1214 | 8.58E-06 | -3.7 | 8.58E-06 | -3.0 | putative oligopeptide ABC transporter integral membrane protein (fragment) | opp-2B | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c1912s1635_a_at | SA1225* | 8.90E-06 | -54.6 | 8.90E-06 | -7.7 | aspartokinase II in bifunctional enxyme: aspartokinase II; homoserine dehydrogenase II | lys C | Amino acid transport and metabolism |
sa_c1918s1640_a_at | SA1226* | 1.78E-05 | -21.5 | 1.78E-05 | -4.3 | aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASA DH) | asd | Amino acid transport and metabolism |
sa_c1922s1644_a_at | SA1227* | 2.75E-07 | -27.3 | 2.75E-07 | -5.2 | dihydrodipicolinate synthase (DHDPS) | dap A | Amino acid transport and metabolism, Cell envelope biogenesis, outer membrane |
sa_c1924s1648_a_at | SA1228* | 1.17E-07 | -31.4 | 1.17E-07 | -5.1 | dihydrodipicolinate reductase (DHPR) | dap B | Amino acid transport and metabolism |
sa_c1928s1652_a_at | SA1229* | 2.55E-07 | -23.5 | 2.55E-07 | -4.4 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | dap D | Amino acid transport and metabolism |
sa_c1936s1659_a_at | SA1231 | 8.94E-08 | -18.5 | 8.94E-08 | -3.0 | Ala_racemase, Alanine racemase | Â | Cell envelope biogenesis, outer membrane |
sa_c3202s2750_a_at | SA1544 | 2.74E-05 | -15.8 | 2.74E-05 | -3.8 | serine-pyruvate aminotransferase; alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase) | Â | Amino acid transport and metabolism |
sa_c3603s3083_a_at | SA1659 | 7.54E-06 | -2.4 | 7.54E-06 | -3.5 | parvulin-like PPIase precursor (Peptidyl-prolyl cis-trans isomerase plp) (Rotamase plp) | prs A | Posttranslational modification, protein turnover, chaperones |
sa_c10591s11046_s_at | SA1814 | 1.99E-05 | -3.3 | 1.99E-05 | -2.9 | succinyl-diaminopimelate desuccinylase (dapE) | Â | Amino acid transport and metabolism |
sa_c5023s4322_at | SA2082 | 6.38E-07 | -3.5 | 6.38E-07 | -5.5 | urease gamma chain (urea amidohydrolase) | ure A | Amino acid transport and metabolism |
sa_c5029s4326_a_at | SA2083 | 2.01E-06 | -4.3 | 2.01E-06 | -7.6 | URE2_staxy urease beta subunit | ure B | Amino acid transport and metabolism |
sa_c5031s4330_a_at | SA2084 | 1.84E-07 | -3.0 | 1.84E-07 | -4.4 | urease alpha chain (urea amidohydrolase) | ure C | Amino acid transport and metabolism |
sa_c5035s4334_at | SA2085 | 1.71E-05 | -2.9 | 1.71E-05 | -4.2 | urease accessory protein UreE | ure E | Posttranslational modification, protein turnover, chaperones |
sa_c5039s4340_a_at | SA2086 | 1.40E-05 | -2.3 | 1.40E-05 | -3.8 | urease accessory protein UreF | ure F | Posttranslational modification, protein turnover, chaperones |
sa_c9293s8136_a_at | SA2088 | 0.000118 | -2.2 | 0.000118 | -2.8 | urease accessory protein UreD | ure D | Posttranslational modification, protein turnover, chaperones |
sa_c5303s4583_a_at | SA2149 | 1.28E-07 | -35.8 | 1.28E-07 | -64.9 | probable peptide ABC transporter ATP-binding ABC transporter protein | Â | hypothetical protein |
sa_c5307s4587_at | SA2150 | 9.33E-07 | -36.5 | 9.33E-07 | -69.0 | ABC-type transporter, permease component | Â | hypothetical protein |
sa_c5777s5020_a_at | SA2235 | 2.82E-05 | -5.1 | 2.82E-05 | -3.5 | putative ABC transporter; osmoprotectant-binding protein, | opu CC | Cell envelope biogenesis, outer membrane |
sa_c6435s5604_a_at | SA2409 | 0.000134 | -4.6 | 0.000134 | -2.2 | anaerobic ribonucleoside-triphosphate reductase activating protein | Â | Posttranslational modification, protein turnover, chaperones |
Group V: Downregulation (20 min) – No change (60 min) 35 genes | ||||||||
sa_c37s34_a_at | SA0010 | 2.44E-06 | -4.7 | Â | Â | branched-chain amino acid permease | Â | Amino acid transport and metabolism |
sa_c4055s3432_a_at | SA0201 | 0.00111 | -2.3 | Â | Â | RGD-containing lipoprotein | rlp | Amino acid transport and metabolism |
sa_c7055s6165_a_at | SA0331 | 0.000236 | -3.0 | Â | Â | probable lipoprotein | Â | Inorganic ion transport and metabolism |
sa_c7100s6210_a_at | SA0344 | 2.80E-06 | -15.2 |  |  | methyltetrahydropteroyltriglutamate – homocysteine methyltransferase (vitamin-B12-independent methionine synthase isozyme) | met E | Amino acid transport and metabolism |
sa_c5418s4689_a_at | SA0420 | 7.55E-05 | -2.8 | Â | Â | probable amino acid ABC transporter, ATP-binding protein (abc) | Â | Inorganic ion transport and metabolism |
sa_c7374s6406_a_at | SA0421 | 6.63E-07 | -3.3 | Â | Â | putative amino acid ABC transporter, permease protein, glutamine transport system | Â | Inorganic ion transport and metabolism |
sa_c5431s4700_a_at | SA0769 | 2.32E-06 | -5.4 | Â | Â | probable amino acid ABC transporter, ATP-binding protein | Â | Inorganic ion transport and metabolism |
sa_c8512s7471_a_at | SA0770 | 1.42E-05 | -6.3 | Â | Â | permease protein of ABC transporter system | Â | Inorganic ion transport and metabolism |
sa_c8518s7475_a_at | SA0771 | 5.12E-06 | -7.5 | Â | Â | probable D-methionine-binding lipoprotein metQ precursor (Outer membrane lipoprotein1) | Â | Inorganic ion transport and metabolism |
sa_c350s191_a_at | SA0849 | 8.12E-05 | -2.1 | Â | Â | oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-2) | Â | Amino acid transport and metabolism |
sa_c352s195_a_at | SA0850 | 0.000757 | -3.4 | Â | Â | periplasmic oligopeptide-binding protein of oligopeptide ABC transporter | Â | Amino acid transport and metabolism |
sa_c1820s1547_a_at | SA1200 | 0.00698 | -2.1 | Â | Â | para-aminobenzoate synthetase glutamine amidotransferase component II | Â | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c1828s1551_a_at | SA1201 | 0.000803 | -2.8 | Â | Â | pir|AE0653 anthranilate synthase component II, | trp D | Amino acid transport and metabolism |
sa_c1832s1558_a_at | SA1202 | 0.00239 | -4.5 | Â | Â | anthranilate synthase; indole-glycerol phosphate synthase; | trp C | Amino acid transport and metabolism |
sa_c1836s1562_at | SA1203 | 0.00279 | -4.3 | Â | Â | indole-3-glycerolphosphate synthetase | trp F | Amino acid transport and metabolism |
sa_c1840s1566_a_at | SA1204 | 0.000663 | -3.6 | Â | Â | tryptophan synthase beta chain; tryptophan synthase (beta subunit) | trp B | Amino acid transport and metabolism |
sa_c1844s1570_a_at | SA1205 | 5.52E-05 | -2.6 | Â | Â | tryptophan synthase alpha chain; tryptophan synthase | trp A | Amino acid transport and metabolism |
sa_c1866s1587_a_at | SA1211 | 0.000158 | -2.3 | Â | Â | ATP-binding ABC transporter protein | opp-2F | Amino acid transport and metabolism |
sa_c4209s3561_a_at | SA1858 | 0.000144 | -6.2 | Â | Â | dihydroxy-acid dehydratase (DAD) | ilv D | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c4213s3565_a_at | SA1859 | 0.000431 | -8.0 | Â | Â | acetolactate synthase isozyme III large subunit (AHAS-III) | ilv B | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c9931s8627_a_at | SA1861 | 0.000255 | -10.3 | Â | Â | ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase) | ilv C | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c4223s3575_a_at | SA1862 | 4.06E-05 | -9.8 | Â | Â | 2-isopropylmalate synthase | leu A | Amino acid transport and metabolism |
sa_c4225s3576_a_at | SA1863 | 5.85E-05 | -11.0 | Â | Â | 3-isopropylmalate dehydrogenase | leu B | Energy production and conversion, Amino acid transportand metabolism |
sa_c4229s3580_a_at | SA1864 | 1.39E-05 | -13.2 | Â | Â | 3-isopropylmalate dehydratase large subunit | leu C | Amino acid transport and metabolism |
sa_c4239s3588_a_at | SA1865 | 6.09E-05 | -13.1 | Â | Â | 3-isopropylmalate dehydratase small subunit | leu D | Amino acid transport and metabolism |
sa_c4243s3594_a_at | SA1866 | 1.58E-05 | -7.3 | Â | Â | threonine dehydratase biosynthetic (Threonine deaminase) (TD) | ilv A | Amino acid transport and metabolism |
sa_c9447s10370cs_s_at | SA2464* | 0.00225 | -10.5 | Â | Â | histidine biosynthesis bifunctional protein | his I | Amino acid transport and metabolism |
sa_c6696s10090cs_s_at | SA2465* | 0.00199 | -10.6 | Â | Â | Imidazole glycerol phosphate synthase subunit hisF | his F | Amino acid transport and metabolism |
sa_c6706s5846_a_at | SA2466* | 0.00148 | -14.5 | Â | Â | phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase | Â | Amino acid transport and metabolism |
sa_c6708s5850_a_at | SA2467 | 0.00213 | -14.6 | Â | Â | Imidazole glycerol phosphate synthase subunit hisH | his H | Amino acid transport and metabolism |
sa_c6714s5853_a_at | SA2468* | 0.00639 | -13.6 | Â | Â | Imidazoleglycerol-phosphate dehydratase (IGPD) | his B | Amino acid transport and metabolism |
sa_c6718s5857_a_at | SA2469 | 0.00106 | -19.8 | Â | Â | histidinol-phosphate aminotransferase | Â | Amino acid transport and metabolism |
sa_c6728s5871_a_at | SA2472 | 0.0059 | -14.5 | Â | Â | ATPphosphoribosyltransferase regulatory subunit | his Z | Amino acid transport and metabolism |
sa_c6740s5882_a_at | SA2475 | 0.000217 | -6.6 |  |  | ABC transporter membrane-spanning permease – unknown substrate |  | Inorganic ion transport and metabolism |
sa_c5397s4673_a_at | SA2476 | 0.000459 | -7.6 | Â | Â | putative ABC transporter; ATP-binding protein; possible cobalt transport system | Â | Inorganic ion transport and metabolism |
Group VI: No change (20 min) – Downregulation (60 min) 19 genes | ||||||||
sa_c2346s1974_a_at | SA0144 | Â | Â | 4.02E-05 | -3.1 | capsular polysaccharide synthesis enzyme Cap5A | cap A | Cell envelope biogenesis, outer membrane |
sa_c2385s1987_a_at | SA0145 | Â | Â | 4.55E-06 | -2.9 | capsular polysaccharide synthesis enzyme Cap5B | cap B | Cell division and chromosome partitioning |
sa_c2399s1991_a_at | SA0146 | Â | Â | 0.00055 | -2.6 | capsular polysaccharide synthesis enzyme Cap8C | cap C | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c2413s1997_a_at | SA0147 | Â | Â | 0.0001 | -2.6 | capsular polysaccharide synthesis enzyme Cap5D | cap D | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c9546s8318_a_at | SA0148 | Â | Â | 9.77E-05 | -2.8 | putative UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose 4-epimerase) | cap E | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c2479s2056_a_at | SA0149 | Â | Â | 2.40E-06 | -3.1 | capsular polysaccharide synthesis enzyme Cap5F | cap F | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c2516s2092_a_at | SA0150 | Â | Â | 5.92E-05 | -2.4 | UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc-2-epimerase) | cap G | Cell envelope biogenesis, outer membrane |
sa_c10086s8810_a_at | SA0151 | Â | Â | 0.00025 | -2.8 | chloramphenicol acetyltransferase (Xenobiotic acetyltransferase) (XAT) | cap H | General function prediction only |
sa_c10087s8814_a_at | SA0152 | Â | Â | 0.00017 | -2.7 | capsular polysaccharide synthesis enzyme Cap5I | cap I | Cell envelope biogenesis, outer membrane |
sa_c10089s8822_a_at | SA0154 | Â | Â | 0.00103 | -2.1 | capsular polysaccharide synthesis enzyme Cap5K | cap K | Cell envelope biogenesis, outer membrane |
sa_c898s698_a_at | SA0977 | Â | Â | 0.00044 | -2.7 | 29-kDa cell surface protein | isd A | Cell envelope biogenesis, outer membrane |
sa_c906s704_a_at | SA0978 | Â | Â | 0.00538 | -2.2 | hypothetical protein SirD | isd C | Cell envelope biogenesis, outer membrane |
sa_c3380s9339_a_at | SA1586 | Â | Â | 1.41E-05 | -2.4 | 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) | rib H | Coenzyme metabolism |
sa_c3387s2918_a_at | SA1587 | Â | Â | 6.15E-06 | -2.8 | probable riboflavin biosynthesis bifunctional protein | rib A | Coenzyme metabolism |
sa_c3391s2919_a_at | SA1588 | Â | Â | 3.10E-06 | -2.7 | riboflavin synthase alpha chain | rib B | Coenzyme metabolism |
sa_c3395s2925_a_at | SA1589 | Â | Â | 5.10E-07 | -3.0 | riboflavin specific deaminase | rib D | Coenzyme metabolism |
sa_c4369s3721_at | SA1894 | Â | Â | 0.000661 | -2.3 | thiamine-phosphate pyrophosphorylase | thi E | Coenzyme metabolism |
sa_c4373s3725_a_at | SA1895 | Â | Â | 3.05E-05 | -2.5 | hydroxyethylthiazole kinase | thi M | Coenzyme metabolism |
sa_c4379s3726_a_at | SA1896 | Â | Â | 0.000137 | -2.8 | bifunctional enzyme: hydroxy-phosphomethylpyrimidine kinase | thi D | Coenzyme metabolism |
Group VII: Downregulation (20 min) – Upregulation (60 min) 3 genes | ||||||||
sa_c9442s8255_a_at | SA2459* | 0.0016 | -2.5 | 0.0016 | 2.5 | intercellular adhesion protein IcaA | ica A | Cell envelope biogenesis, outer membrane |
sa_c6677s5830_a_at | SA2460* | 0.0136 | -2.0 | 0.0136 | 4.7 | IcaD | ica D | Cell envelope biogenesis, outer membrane |
sa_c6681s9106_a_at | SA2461* | 3.83E-06 | -2.1 | 3.83E-06 | 3.4 | intercellular adhesion protein IcaB | ica B | Cell envelope biogenesis, outer membrane |