Figure 3

A. Neighbour-Net tree of all Metallophosphatase type (PPP) domains detected in the model genomes. The coloured wedges indicate the distinct clusters defined by the Markov clustering algorithm, which are labelled according to the consensus of annotations available in Swiss-Prot/Trembl/. P. falciparum sequences appearing in the tree are labelled by capital letters: A-I Plasmodium falciparum PPP type phosphatase domains (see Fig. 3B for identification) J, PF14_0036; K, PF13_0222; L, PF4390w; M, PF14_0064; N, PF14_0614; O, PF14_0660; P, PFL0300c. Sequences J-M are not expected to encode protein phosphatases. The organisms from which the sequences originate are colour-coded as follows: Red and boxed, P. falciparum (Alveolates); green, A. thaliana (Plants); Blue, H. Sapiens (Opisthokonts); Turquoise, G. lamblia (Excavates); purple, T, brucei (Discicristates); black, T. pseudonana (Heterokonts); and magenta, D. discoideum (Amoebozoa). B. Enlargement of the region of the Metallophosphatase type domain Neighbour-Net tree of PPP phosphatase domains. Most domain types are labelled according to the human homologue, where present. P. falciparum sequences appearing in the tree are labelled by capital letters: A, PF14_0630; B, PF14_0142; C, PF14_0224; D, PFC0595c; E, PF10_0177; F, PF08_0129; G, PFI1245c; H, PFI1360c; I, MAL13P1.274. A high-resolution version of this Figure is available as a PNG file (see Additional file 7). We recommend viewing this file using a graphics programme enabling magnification, such as Microsoft Office Picture Manager.}