Table 2 Novel polymorphisms of phoP-phoR in BCG strains identified in current study.
From: Novel genome polymorphisms in BCG vaccine strains and impact on efficacy
BCG strains | Polymorphisms of phoP | Predicted effects on PhoP | Polymorphisms phoR | Predicted effects on PhoR |
|---|---|---|---|---|
Russia Japan Moreau | IS6110 insertion at 18 bp upstream of ATG start codon | Upregulation of phoP | One SNP in BCG-Moreau. No SNP in BCG-Russia or -Japan | D322G mutant in BCG-Moreau |
Birkhaug Sweden | ND | NA | 11 bp deletion within ORF | Mutated 54 residues of the C-terminal |
Prague | Single base insertion within ORF | Mutated 94 residues of the C-terminal | ND | NA |
Frappier | SNP within ORF | T9M mutant | Single base deletion within ORF | Mutated 383 residues of the C-terminal |
China | SNP within ORF | P151S mutant | ND | NA |