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Table 1 Responses to TCDD Common to Mouse and Rat

From: Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: Comparison of rat and mouse

 

Entrez Gene ID

M Value

Gene Symbol

Mouse Gene Name

HID

Mouse

Rat

Mouse

Rat

Mouse

Rat

 

68062

13076

24296

9.58

11.06

Cyp1a1

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

68035

13078

25426

8.23

9.46

Cyp1b1

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

9167

99929

310467

6.83

4.07

Tiparp

Tiparp _predicted

TCDD-inducible poly(ADP-ribose) polymerase

695

18104

24314

4.52

3.05

Nqo1

Nqo1

NAD(P)H dehydrogenase, quinone 1

81752

21743

368066

-1.21

-5.66

Inmt

LOC368066

indolethylamine N-methyltransferase

90898

29858

300089

4.56

1.62

Pmm1

Pmm1

phosphomannomutase 1

38296

211446

252881

1.79

2.99

Exoc3

Exoc3

exocyst complex component 3

22419

12778

84348

1.36

3.19

Cxcr7

Cmkor1

chemokine (C-X-C motif) receptor 7

2412

18024

83619

2.35

2.15

Nfe2l2

Nfe2l2

nuclear factor, erythroid derived 2, like 2

56841

78798

313861

1.55

2.60

Eml4

Eml4 _predicted

echinoderm microtubule associated protein like 4

32722

76650

296271

1.90

2.10

Srxn1

Srxn1

sulfiredoxin 1 homolog (S. cerevisiae)

68082

13077

24297

2.36

1.27

Cyp1a2

Cyp1a2

cytochrome P450, family 1, subfamily a, polypeptide 2

2252

20969

25216

-1.16

-1.77

Sdc1

Sdc1

syndecan 1

31150

78610

308846

0.72

1.43

Uvrag

LOC308846

UV radiation resistance associated gene

31384

117198

289089

-0.68

-1.29

Ivns1abp

Ivns1abp_predicted

influenza virus NS1A binding protein

1952

207728

81743

1.10

0.84

Pde2a

Pde2a

phosphodiesterase 2A, cGMP-stimulated

375

18010

24591

0.45

1.27

Neu1

Neu1

neuraminidase 1

37872

70266

311844

-0.53

2.22

Ccbl1

Ccbl1

cysteine conjugate-beta lyase 1

41470

68371

171564

0.57

1.03

Pbld

Mawbp

phenazine biosynthesis-like protein domain containing

86978

28248

50572

-0.50

-1.07

Slco1a1

Slco1a1

solute carrier organic anion transporter family, member 1a1

55580

78943

498013

-0.69

-0.81

Ern1

RGD1559716 _predicted

Endoplasmic reticulum (ER) to nucleus signalling 1

134

14600

25235

-0.44

-1.05

Ghr

Ghr

growth hormone receptor

11098

64058

292949

0.37

0.97

Perp

Perp _predicted

PERP, TP53 apoptosis effector

4480

16796

29278

-0.75

-0.57

Lasp1

Lasp1

LIM and SH3 protein 1

11483

67819

362912

0.57

0.71

Derl1

RGD1311835

Der1-like domain family, member 1

55885

14661

24399

-0.27

-1.00

Glud1

Glud1

glutamate dehydrogenase 1

7673

12822

85251

-0.46

-0.52

Col18a1

Col18a1

procollagen, type XVIII, alpha 1

41475

109672

64001

0.55

0.41

Cyb5

Cyb5

cytochrome b-5

41077

66537

288455

0.56

0.32

Pomp

RGD1305831 _predicted

proteasome maturation protein

55884

11692

27100

0.47

0.36

Gfer

Gfer

growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)

2090

19172

58854

0.29

0.38

Psmb4

Psmb4

proteasome (prosome, macropain) subunit, beta type 4

55520

14261

25256

1.13

-1.23

Fmo1

Fmo1

flavin containing monooxygenase 1

88552

22003

24851

1.09

-1.07

Tpm1

Tpm1

tropomyosin 1, alpha

  1. Following pre-processing, a linear-modeling approach was used to identify ProbeSets associated with TCDD response in each species. ProbeSets were mapped to Entrez Gene IDs using the Affymetrix annotation (version na24). Orthologous genes were identified using the Homologene database (build 58). This table lists genes that display statistically significant (padjusted < 0.01) changes in mRNA abundance in both species. The M-values represent the magnitude of difference in expression caused by TCDD exposure in log2 space. For example, Cyp1a1 has an M-value of 11.1 in rat, indicating 2,194-fold induction in response to TCDD treatment