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Table 1 Responses to TCDD Common to Mouse and Rat

From: Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: Comparison of rat and mouse

  Entrez Gene ID M Value Gene Symbol Mouse Gene Name
HID Mouse Rat Mouse Rat Mouse Rat  
68062 13076 24296 9.58 11.06 Cyp1a1 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
68035 13078 25426 8.23 9.46 Cyp1b1 Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1
9167 99929 310467 6.83 4.07 Tiparp Tiparp _predicted TCDD-inducible poly(ADP-ribose) polymerase
695 18104 24314 4.52 3.05 Nqo1 Nqo1 NAD(P)H dehydrogenase, quinone 1
81752 21743 368066 -1.21 -5.66 Inmt LOC368066 indolethylamine N-methyltransferase
90898 29858 300089 4.56 1.62 Pmm1 Pmm1 phosphomannomutase 1
38296 211446 252881 1.79 2.99 Exoc3 Exoc3 exocyst complex component 3
22419 12778 84348 1.36 3.19 Cxcr7 Cmkor1 chemokine (C-X-C motif) receptor 7
2412 18024 83619 2.35 2.15 Nfe2l2 Nfe2l2 nuclear factor, erythroid derived 2, like 2
56841 78798 313861 1.55 2.60 Eml4 Eml4 _predicted echinoderm microtubule associated protein like 4
32722 76650 296271 1.90 2.10 Srxn1 Srxn1 sulfiredoxin 1 homolog (S. cerevisiae)
68082 13077 24297 2.36 1.27 Cyp1a2 Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
2252 20969 25216 -1.16 -1.77 Sdc1 Sdc1 syndecan 1
31150 78610 308846 0.72 1.43 Uvrag LOC308846 UV radiation resistance associated gene
31384 117198 289089 -0.68 -1.29 Ivns1abp Ivns1abp_predicted influenza virus NS1A binding protein
1952 207728 81743 1.10 0.84 Pde2a Pde2a phosphodiesterase 2A, cGMP-stimulated
375 18010 24591 0.45 1.27 Neu1 Neu1 neuraminidase 1
37872 70266 311844 -0.53 2.22 Ccbl1 Ccbl1 cysteine conjugate-beta lyase 1
41470 68371 171564 0.57 1.03 Pbld Mawbp phenazine biosynthesis-like protein domain containing
86978 28248 50572 -0.50 -1.07 Slco1a1 Slco1a1 solute carrier organic anion transporter family, member 1a1
55580 78943 498013 -0.69 -0.81 Ern1 RGD1559716 _predicted Endoplasmic reticulum (ER) to nucleus signalling 1
134 14600 25235 -0.44 -1.05 Ghr Ghr growth hormone receptor
11098 64058 292949 0.37 0.97 Perp Perp _predicted PERP, TP53 apoptosis effector
4480 16796 29278 -0.75 -0.57 Lasp1 Lasp1 LIM and SH3 protein 1
11483 67819 362912 0.57 0.71 Derl1 RGD1311835 Der1-like domain family, member 1
55885 14661 24399 -0.27 -1.00 Glud1 Glud1 glutamate dehydrogenase 1
7673 12822 85251 -0.46 -0.52 Col18a1 Col18a1 procollagen, type XVIII, alpha 1
41475 109672 64001 0.55 0.41 Cyb5 Cyb5 cytochrome b-5
41077 66537 288455 0.56 0.32 Pomp RGD1305831 _predicted proteasome maturation protein
55884 11692 27100 0.47 0.36 Gfer Gfer growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
2090 19172 58854 0.29 0.38 Psmb4 Psmb4 proteasome (prosome, macropain) subunit, beta type 4
55520 14261 25256 1.13 -1.23 Fmo1 Fmo1 flavin containing monooxygenase 1
88552 22003 24851 1.09 -1.07 Tpm1 Tpm1 tropomyosin 1, alpha
  1. Following pre-processing, a linear-modeling approach was used to identify ProbeSets associated with TCDD response in each species. ProbeSets were mapped to Entrez Gene IDs using the Affymetrix annotation (version na24). Orthologous genes were identified using the Homologene database (build 58). This table lists genes that display statistically significant (padjusted < 0.01) changes in mRNA abundance in both species. The M-values represent the magnitude of difference in expression caused by TCDD exposure in log2 space. For example, Cyp1a1 has an M-value of 11.1 in rat, indicating 2,194-fold induction in response to TCDD treatment