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Table 2 Selected Enriched Gene Ontology Categories

From: Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: Comparison of rat and mouse

GO ID

Rat

Mouse

Common

GO Term

GO:0006118

3.33E-04

3.43E-01

8.43E-03

electron transport

GO:0006984

1.01E+00

1.00E+00

9.67E-03

ER-nuclear signaling pathway

GO:0006986

1.02E+00

1.01E+00

1.10E-02

response to unfolded protein

GO:0005792

2.89E-01

7.64E-01

1.30E-02

microsome

GO:0020037

7.99E-01

9.21E-01

2.61E-02

heme binding

GO:0016491

1.00E-04

2.71E-03

4.02E-02

oxidoreductase activity

GO:0005832

9.99E-01

2.82E-02

1.01E+00

chaperonin-containing T-complex

GO:0006412

1.04E+00

1.11E-04

1.02E+00

translation

GO:0030529

1.04E+00

1.00E-04

1.02E+00

ribonucleoprotein complex

GO:0030151

1.01E+00

1.81E-02

1.03E+00

molybdenum ion binding

GO:0008610

7.20E-02

5.74E-01

1.05E+00

lipid biosynthetic process

GO:0044255

1.18E-02

3.72E-02

1.15E+00

cellular lipid metabolic process

  1. Genes differentially expressed in each species were selected at padjusted < 0.01 using linear-modeling analysis. The set of genes whose mRNA levels were altered by TCDD in only mice, only rats, or in both species were separately subjected to Gene Ontology enrichment analysis to identify specific pathways or functions modulated. A selection of enriched GO terms is shown. The numeric values are false-discovery rates estimated by 1,000 permutations of the input data. Only a subset of GO categories is shown. Bold text indicates those categories significant at a 10% false-discovery rate.