Figure 6
From: Interspecies data mining to predict novel ING-protein interactions in human
Merger of the interaction maps for the three human proteins ING1, MEKK, and p38a (p38MAPK) based on empirical data retrieved from the STRING database. Lines connecting p38a and its interactors have been excluded for clarity, except where the interactor is directly shared with MEKK4 as part of a well-defined stress response pathway. MEKK4 and ING1 have relative few confirmed interactions, but the interactions predicted and confirmed in our study (shown as thick lines) are the first to directly tie ING1 to multiple key proteins in this stress response. Examining such interaction overlap graphs can help, in deciding which interaction predictions to validate biochemically, based on biological tenability and salience.