Interspecies data mining to predict novel ING-protein interactions in human

BMC Genomics

Table 2 Comparison of ING results for existing protein interaction prediction tools.

Prediction Tool	Total number of Interactions	ING1/2/3 interactions	Interactions not in existing STRING dataset	Overlap with predictions from this work
I2D [78]	200,599	33	2	0
YeastNet [77]#	102,803	100	57	0
OPHID [41]	47,221	10	2	0
POINT [43]	45,378	49	26	1^
Ulysses [42]	26,797	22	15	1*
Predict [79]	20,088	5	5	1*

# A yeast database
^The concurring interactor, PDI1, was excluded from the 5 core predictions of this work due to weakness of the human homolog (see Figure 4)
* The concurring interactor, CDC37, was excluded from the 5 core predictions of this work due to weakness of the human homolog (see Figure 4)

ISSN: 1471-2164