Table 4 Known function of immune system GPCRs
Cytokine receptors | |
|---|---|
Chemokine (C-C motif) receptor 5 | Stimulates leukocyte chemotactic activity |
Chemokine (C-C motif) receptor 6 | Associated with mature memory B cells |
Chemokine (C-X-C motif) receptor 3 splice 2 | Transduction of angiostatic effect of cytokines in microvascular endothelial cells |
Chemokine (C-X-C motif) receptor 4 | Neuronal survival; maintaining of highly differentiated neurons; axon guidance |
Chemokine (C-X-C motif) receptor 7 | Co-receptor for CXCR4 in B-, T-cells and monocytes |
Chemokine (C-X-C motif) receptor 5 | B-cell activation and chemoattraction |
Non-cytokine receptors | |
EBV-induced G-protein coupled receptor 2 | B-lymphocyte and promyelocytic (glial precursor) cell line regulation |
GPR34 | Lysophosphatidylserine receptor in mast cells; wound healing |
GPR81 | Exclusively expressed in T-cells; neurotensin-related |
GPR132 | Mitosis delay under control of lysophosphatidylcholine in lymphocytes and macrophages |
Leukotriene B(4) receptor 2 | Chemotaxis of mononuclear lymphocytes |
Prostaglandin E2 receptor EP4 (PTGER4) | Stimulates immune response in B-cells and monocytes |
P2Y10 (putative nucleotide receptor) | Monocyte development |