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Table 10 The superfamily of Ras small GTPases

From: The information highways of a biotechnological workhorse – signal transduction in Hypocrea jecorina

Ras subfamily

Ras GTPase

RasGEF

RasGAP

 

YPT1

 

tre22132

 

tre17707

tre30910

 

tre121349

 

tre44333

tre75397

 

Rab

tre44010

 

tre65982

tre44704

tre44251

 

tre33269

tre31007

tre42061

tre42834

tre29515

  
   

tre35375

 

tre21294

tre106302

tre41009

tre5278

  

Rho

CDC42

tre30184

tre74848

 

GEM1

  
 

tre53562

RHO3

 

tre14881

tre46043

 

RHO1

tre37105

tre80713

 

tre107035

tre66480

  
 

RAS1

  
 

tre34726

tre61408

tre22757

 

Ras

RAS2

  
  

tre107369

 
 

RSR1 (Rap-like)

 

tre81785

  

tre67275

 
  

tre70548

 

Ran

RAN1

  
 

tre28367

tre43177

  
 

tre29890

tre28378

 

Arf-like

tre45468

tre29839

 
 

tre38187

tre37547

 
 

tre42316

SAR1

  

Rac

RAC1

  

undetermined

  

tre62426

tre37068

  1. The respective small GTPases are grouped according to their assigned subfamily as suggested by the presence of appropriate protein domains determined by InterPro and NCBI CDD search as well as due to their similarity to known orthologues in GenBank. Guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) have been associated with the respective GTPase(s), provided that the regulatory target of the orthologue in yeast was known.