Table 1 Microarray gene expression fold change values for 18 significant genes within the non-infected control animal group (n = 6) and the BTB-infected animal group (n = 6) between T0 and T3.
Gene symbol | Gene name | BOTL clone ID | Gene ontology (GO) function/s | Fold change infected cattle | Fold change control cattle |
|---|---|---|---|---|---|
SDS | Serine dehydratase | BOTL0100002XA02R | Amino acid metabolism | +1.72 ± 0.20 | -1.85 ± 0.26 |
GLTSCR2 | Glioma tumor suppressor candidate region gene 2 | BOTL0100002XB07R | Unknown | +1.98 ± 0.24 | -1.92 ± 0.34 |
TLE3 | Transducin-like enhancer of split 3 | BOTL0100003XG08R | Regulation of gene transcription | +1.69 ± 0.13 | -1.86 ± 0.30 |
DUSP10 | Dual specificity phosphatase 10 | BOTL0100004XG06R | Phosphatase activity and response to stress | -1.44 ± 0.18 | +1.57 ± 0.25 |
LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | BOTL0100006XH06R | Amino acid phosphorylation and receptor signalling | +1.98 ± 0.21 | -1.70 ± 0.34 |
Unknown | - | BOTL0100008_A05 | Unknown | +1.80 ± 0.19 | -1.73 ± 0.16 |
SYNCRIP | Synaptotagmin binding, cytoplasmic RNA interacting protein | BOTL0100009_E08 | RNA binding | -1.36 ± 0.09 | +1.58 ± 0.23 |
PKM2 | Pyruvate kinase | BOTL0100010_C03 | Protein binding and alternative splicing | +1.63 ± 0.21 | -1.47 ± 0.52 |
GIMAP1 | GTPase, IMAP family member 1 | BOTL0100011_B07 | Control of cell survival and nucleotide binding | +1.40 ± 0.18 | -1.49 ± 0.13 |
TAF6 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor | BOTL0100012_G05 | Regulation of transcription | +1.87 ± 0.31 | -1.42 ± 0.17 |
Unknown | - | BOTL0100013_F01 | Unknown | +1.52 ± 0.13 | -1.38 ± 0.12 |
HCFC1 | Similar to Host cell factor C1 | BOTL0100013_G06 | Regulation of transcription | +1.78 ± 0.15 | -1.76 ± 0.21 |
GATA4 | GATA binding protein 4 | GATA binding protein 4 (GATA4) | Regulation of transcription | +2.49 ± 0.29 | -3.56 ± 0.20 |
CSF2RA | Colony stimulating factor 2 receptor, alpha | colony stimulating factor 2 receptor, alpha) | Production, differentiation, and function of granulocytes and macrophages | +3.76 ± 0.41 | -2.46 ± 0.26 |
SFRS2 | Splicing factor, arginine/serine-rich 2 | NBFGC_BE721857 chemokine (C-C motif) receptor 7 (CCR7) | mRNA processing | +2.52 ± 0.24 | -1.63 ± 0.19 |
AXL | AXL receptor tyrosine kinase | NBFGC_BE722178 AXL receptor tyrosine kinase | Signal transduction | -1.36 ± 0.13 | +1.87 ± 0.31 |
EEF1G | Eukaryotic translation elongation factor 1 gamma | NBFGC_BF230159 EEF1G eukaryotic translation elongation | Translational elongation | +2.24 ± 0.15 | -1.46 ± 0.24 |
CCL1 | Chemokine (C-C motif) ligand 1 | Small inducible cytokine A1 | Chemokine activity | +5.13 ± 0.34 | -2.57 ± 0.36 |