Figure 1

Relative conservation of SLiMs. (A) Low relative conservation of a conserved SLiM in an overall highly conserved protein. Sequence alignment of Histone H3.1 with potential SH2 binding Tyr-SLiMs in red boxes (upper panel). Schematic illustration and alignment around Y54 of Histone H3.1 are shown below. (B) High relative conservation of a conserved SLiM in an overall less-conserved protein. C-terminal sequence alignment of IL4R with potential SH2 binding Tyr-SLiMs shown in red boxes (upper panel). Schematic illustration of relative conservation and alignment around Y631 and Y821 of IL4R are shown below.