The conservation pattern of short linear motifs is highly correlated with the function of interacting protein domains

Table 2 Molecular functional classes frequently reported to interact with SH2, SH3 or PDZ domains, or to be phosphorylated by S/T kinases

Domain	Molecular function	Binding ratio*
SH2	Receptor kinase/phosphatase	0.53
	Tyrosine kinase/phosphatase	0.51
	Cytokine/Immune receptor	0.36
	Adapter molecule	0.20
	Cell surface receptor	0.14
SH3	Tyrosinekinase/phosphatase	0.32
	Adapter molecule	0.18
	Guanine nucleotide exchange factor	0.12
	Cytoskeletal protein	0.11
	GTPase activating protein	0.11
PDZ	Channel	0.214
	Adhesion molecule	0.075
	Cell surface receptor	0.052
Kinase		Phospho ratio ^#
S/T Kinase	Serine/threonine kinase/phosphatase	0.00442
	Cell cycle control protein	0.00397
	RNA-binding protein	0.00334
	Transcription factor	0.00320
	Adapter molecule	0.00296
	Structural protein	0.00259
	Transcription regulatory protein	0.00255

* The binding ratio is calculated as the percentage of proteins that interact with proteins containing SH2, SH3, or PDZ domains.
# The phosphorylation ratio is calculated as the ratio of serine residues that are phosphorylated.

ISSN: 1471-2164