Table 2 Pfam domains that are frequently truncated among protein isoforms.
Domain | No. of genes that encode the domain in different lengths among the protein isoforms (& as percentage fraction of genes encoding the domain in the protein isoforms)$ | Count of unique domain lengths @ | Variation in lengths of the domain among isoforms | |
|---|---|---|---|---|
Minimal length | Maximal length | |||
Pkinase | 116 (77%) | 52 | 23 | 572 |
3 (8%) | 5 | 199 | 486 | |
C1-set | 47 (43%) | |||
Not seen in ASD | 8 | 30 | 89 | |
Ras | 38 (92%) | |||
Not seen in ASD | 21 | 25 | 192 | |
MHC_I | 35 (70%) | 7 | 36 | 178 |
3 (60%) | 5 | 91 | 178 | |
Trypsin | 29 (60%) | 23 | 32 | 261 |
20 (66%) | 14 | 104 | 261 | |
ABC_tran | 29 (80%) | 15 | 55 | 197 |
11 (68%) | 9 | 80 | 199 | |
Filament | 26 (92%) | 23 | 34 | 452 |
4 (100%) | 6 | 142 | 400 | |
PH | 24 (25%) | 15 | 26 | 241 |
6 (15%) | 5 | 84 | 134 | |
MFS_1 | 23 (92%) | 33 | 82 | 537 |
6 (54%) | 7 | 326 | 426 | |
Serpin | 22 (100%) | 30 | 31 | 424 |
10 (100%) | 13 | 140 | 378 | |
P450 | 22 (100%) | 22 | 86 | 463 |
13 (72%) | 20 | 187 | 486 | |
Proteasome | 22 (100%) | 11 | 29 | 191 |
9 (100%) | 8 | 117 | 187 | |
7tm_1 | 22 (70%) | 24 | 25 | 459 |
16 (48) | 17 | 149 | 388 | |
Ion_trans | 21 (63) | 18 | 27 | 280 |
1 (10%) | 2 | 208 | 220 | |
RRM_1 | 20 (46%) | 9 | 23 | 86 |
9 (34%) | 4 | 46 | 72 | |
DEAD | 19 (67%) | 17 | 27 | 188 |
9 (56%) | 9 | 96 | 180 | |
Pkinase_Tyr | 19 (38%) | |||
Not seen in ASD | 17 | 50 | 301 | |
Collagen | 19 (37%) | |||
Not seen in ASD | 5 | 28 | 59 | |
Tubulin | 18 (100%) | 13 | 46 | 227 |
2 (50%) | 5 | 113 | 227 | |
I-set | 18 (37%) | |||
Not seen in ASD | 10 | 22 | 99 | |
Helicase_C | 18 (35%) | 7 | 41 | 91 |
3 (12%) | 3 | 55 | 76 | |
Mito_carr | 17 (73%) | 14 | 26 | 146 |
13 (65%) | 10 | 50 | 136 | |
UQ_con | 7 (87%) | 8 | 28 | 144 |
12 (100%) | 11 | 69 | 157 | |