Skip to main content

Table 2 Pfam domains that are frequently truncated among protein isoforms.

From: Splice-mediated Variants of Proteins (SpliVaP) – data and characterization of changes in signatures among protein isoforms due to alternative splicing

Domain No. of genes that encode the domain
in different lengths among the protein
isoforms (& as percentage fraction of genes
encoding the domain in the protein isoforms)$
Count of unique
domain lengths @
Variation in lengths of
the domain among isoforms
    Minimal length Maximal length
Pkinase 116 (77%) 52 23 572
  3 (8%) 5 199 486
C1-set 47 (43%)    
  Not seen in ASD 8 30 89
Ras 38 (92%)    
  Not seen in ASD 21 25 192
MHC_I 35 (70%) 7 36 178
  3 (60%) 5 91 178
Trypsin 29 (60%) 23 32 261
  20 (66%) 14 104 261
ABC_tran 29 (80%) 15 55 197
  11 (68%) 9 80 199
Filament 26 (92%) 23 34 452
  4 (100%) 6 142 400
PH 24 (25%) 15 26 241
  6 (15%) 5 84 134
MFS_1 23 (92%) 33 82 537
  6 (54%) 7 326 426
Serpin 22 (100%) 30 31 424
  10 (100%) 13 140 378
P450 22 (100%) 22 86 463
  13 (72%) 20 187 486
Proteasome 22 (100%) 11 29 191
  9 (100%) 8 117 187
7tm_1 22 (70%) 24 25 459
  16 (48) 17 149 388
Ion_trans 21 (63) 18 27 280
  1 (10%) 2 208 220
RRM_1 20 (46%) 9 23 86
  9 (34%) 4 46 72
DEAD 19 (67%) 17 27 188
  9 (56%) 9 96 180
Pkinase_Tyr 19 (38%)    
  Not seen in ASD 17 50 301
Collagen 19 (37%)    
  Not seen in ASD 5 28 59
Tubulin 18 (100%) 13 46 227
  2 (50%) 5 113 227
I-set 18 (37%)    
  Not seen in ASD 10 22 99
Helicase_C 18 (35%) 7 41 91
  3 (12%) 3 55 76
Mito_carr 17 (73%) 14 26 146
  13 (65%) 10 50 136
UQ_con 7 (87%) 8 28 144
  12 (100%) 11 69 157
  1. $, presents the number of genes that encode the domain as undergoing truncation event among the protein isoforms. In brackets, is given in terms of percentage fraction of genes that encode the domain in the protein isoforms. Values with Vega data set is shown in line 1, and values with ASD data set is shown in line 2.
  2. @, the observed lengths were grouped in a manner that any two lengths that differ by 5 or less amino acids is considered as one unique length.