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Table 4 Unique pairs of alternating Pfam domains

From: Splice-mediated Variants of Proteins (SpliVaP) – data and characterization of changes in signatures among protein isoforms due to alternative splicing

Domains participating in Swap Events (D1 <--> D2)
Domain D1 Domain D2 Description of Domain D1 Description of Domain D2
Hormone_receptor zf-C4 Ligand-binding domain of nuclear hormone receptor. Steroid hormone receptor activity; transcription factor activity. DNA-dependent regulation of transcription. Zinc finger C4 type. Found in steroid/thyroid hormone receptors; transcription factor activity. Regulation of transcription.
KRAB Zf-C2H2 Kruppel-associated box. Nucleic Acid binding; DNA dependent regulation of transcription. Zinc finger. Nucleic acid binding.
SCAN zf-C2H2 SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA). Found in several zf-C2H2 proteins. DNA dependent regulation of transcription. Zinc finger, C2H2 type. Zinc ion binding; nucleic acid binding.
Mito_carr efhand Mitochondrial carrier. Transport EF hand. Calcium ion binding. Signaling. Buffering/transport.
CH Plectin Calponin homology domain. Actin-binding family. Cytoskeletal/signal transduction Plectin repeat. Found in Plakin proteins. Plasma and nuclear membrances.
sushi CUB Sushi domain (SCR repeat) Complement control protein (CCP) modules, or short consensus repeats (SCR). Complement and adhesion. Structural motif in extracellular and plasma membrane-associated proteins.
RGS PDZ Regulator of G protein signaling domain. PDZ domain. Protein binding. Signaling
C2 PDZ Ca2+-dependent membrane-targeting module. Signal transduction/membrane trafficking PDZ domain. Protein binding. Signaling
collagen emi Collagen triple helix repeat. Phosphate transport. Extracellular structural proteins Found in extracellular proteins.
Nebulin LIM Nebulin repeat. Found in the thin filaments of striated vertebrate muscle. Actin-binding protein. LIM domain (Binding protein). Zinc ion binding. Interface for protein-protein interaction
PH Pkinase_Tyr pleckstrin homology. Intracellular signaling/constituent of cytoskeleton. Pkinase_tyr supposed to contain PH domains. Protein tyrosine kinase. Mediates the response to external stimuli.
Tubulin-binding MAP2_projctn Tau and MAP protein. Tubulin-binding repeat. MAP domain (MHC class II analogue protein)
FHA BRCT Forkhead-associated domain. Phosphopeptide binding motif BRCA1 C terminus domain. Phospho-protein binding protein.
NTP_transf_2 PAP_RNA-bind Nucleotidyltransferase domain. Poly(A) polymerase predicted RNA binding domain. Polynucleotide adenyltransferase activity.
Ion_trans Ion_trans_2 Ion transport protein Ion channel. Both are of same clan.
Orn_Arg_deC_N Orn_DAP_Arg_deC Pyridoxal-dependent decarboxylase, pyridoxal binding domain. Catalytic activity Pyridoxal-dependent decarboxylase, C-terminal sheet domain. Catalytic activity.
MAM ig Adhesive function. Cellular component: membrance Immunoglobulin domain
ig I-set Immunoglobulin Immunoglobulin intermediate. Both are of same clan.
I-set V-set Immunoglobulin I-set (intermediate) domain. I-set and V-set are of same clan. Immunoglobulin V-set (variable) domain.
EGF_CA EGF Calcium binding EGF domain. EGF-like protein. Both are of same clan.
Hydrolase E1-E2_ATPase Haloacid dehalogenase-like hydrolase. Catalytic activity. Metabolic process Hydrolase activity. ATP binding.
Radical_SAM Mob_synth_C Catalytic activity; iron-sulfur cluster binding. Molybdenum cofactor synthesis C. iron, sulfur cluster binding
Aconitase Aconitase_C Aconitase hydratase. Lyase activity. Aconitase hydratase. Hydro-lyase activity.
Filament Filament_head Intermediate filament protein. Structural molecule activity Head region of intermediate filaments.
CNH Pkinase Citron and Citron kinase. Small GTPase regulator activity. Protein kinase activity. ATP binding.
PSI Sema Plexin repeat. Membrane. Receptor activity Semaphorins. Secreted and transmembrane proteins.
GTP_EFTU_D2 GTP_EFTU Elongation factor GTP binding. Elongation factor
PARP WWE Poly(ADP-ribose) polymerase. Catalyses covalent attachment of ADP-ribose to DNA binding proteins Mediates protein-protein interactions in ubiquitin and ADP ribose conjugation system.
Sushi An_peroxidase Complement control protein (CCP) modules, or short consensus repeats (SCR). Complement and adhesion Animal haem peroxidase. Peroxidase activity.
PH Oxysterol_BP pleckstrin homology. Intracellular signaling/constituent of cytoskeleton Oxysterol binding protein. Steroid metabolic process
Ank KH_1 Ankyrin repeat. Protein-protein interaction K homology domain. RNA binding
GON TSP_1 Proteinaceous extracellular matrix. Zinc ion binding. Metalloendopeptidase activitiy. Thrombospondin type 1 domain. Cell adhesion
Thioredoxin DnaJ Participates in redox reactions. Heat shock protein binding
Collagen EMI Collagen triple helix repeat. Phosphate transport process. Connective tissue structures. EMI domain. Participates in multimerization
HECT RCC1 HECT-domain (ubiquitin-transferase) Homologous to the E6-AP Carboxyl terminus. Ubiquitin-protein ligase; protein modification process. Regulator of chromose condensation. Acts as a guanine-nucleotide dissociation simulator (GDS)