Table 4 Unique pairs of alternating Pfam domains
Domains participating in Swap Events (D1 <--> D2) | |||
|---|---|---|---|
Domain D1 | Domain D2 | Description of Domain D1 | Description of Domain D2 |
Hormone_receptor | zf-C4 | Ligand-binding domain of nuclear hormone receptor. Steroid hormone receptor activity; transcription factor activity. DNA-dependent regulation of transcription. | Zinc finger C4 type. Found in steroid/thyroid hormone receptors; transcription factor activity. Regulation of transcription. |
KRAB | Zf-C2H2 | Kruppel-associated box. Nucleic Acid binding; DNA dependent regulation of transcription. | Zinc finger. Nucleic acid binding. |
SCAN | zf-C2H2 | SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA). Found in several zf-C2H2 proteins. DNA dependent regulation of transcription. | Zinc finger, C2H2 type. Zinc ion binding; nucleic acid binding. |
Mito_carr | efhand | Mitochondrial carrier. Transport | EF hand. Calcium ion binding. Signaling. Buffering/transport. |
CH | Plectin | Calponin homology domain. Actin-binding family. Cytoskeletal/signal transduction | Plectin repeat. Found in Plakin proteins. Plasma and nuclear membrances. |
sushi | CUB | Sushi domain (SCR repeat) Complement control protein (CCP) modules, or short consensus repeats (SCR). Complement and adhesion. | Structural motif in extracellular and plasma membrane-associated proteins. |
RGS | PDZ | Regulator of G protein signaling domain. | PDZ domain. Protein binding. Signaling |
C2 | PDZ | Ca2+-dependent membrane-targeting module. Signal transduction/membrane trafficking | PDZ domain. Protein binding. Signaling |
collagen | emi | Collagen triple helix repeat. Phosphate transport. Extracellular structural proteins | Found in extracellular proteins. |
Nebulin | LIM | Nebulin repeat. Found in the thin filaments of striated vertebrate muscle. Actin-binding protein. | LIM domain (Binding protein). Zinc ion binding. Interface for protein-protein interaction |
PH | Pkinase_Tyr | pleckstrin homology. Intracellular signaling/constituent of cytoskeleton. Pkinase_tyr supposed to contain PH domains. | Protein tyrosine kinase. Mediates the response to external stimuli. |
Tubulin-binding | MAP2_projctn | Tau and MAP protein. Tubulin-binding repeat. | MAP domain (MHC class II analogue protein) |
FHA | BRCT | Forkhead-associated domain. Phosphopeptide binding motif | BRCA1 C terminus domain. Phospho-protein binding protein. |
NTP_transf_2 | PAP_RNA-bind | Nucleotidyltransferase domain. | Poly(A) polymerase predicted RNA binding domain. Polynucleotide adenyltransferase activity. |
Ion_trans | Ion_trans_2 | Ion transport protein | Ion channel. Both are of same clan. |
Orn_Arg_deC_N | Orn_DAP_Arg_deC | Pyridoxal-dependent decarboxylase, pyridoxal binding domain. Catalytic activity | Pyridoxal-dependent decarboxylase, C-terminal sheet domain. Catalytic activity. |
MAM | ig | Adhesive function. Cellular component: membrance | Immunoglobulin domain |
ig | I-set | Immunoglobulin | Immunoglobulin intermediate. Both are of same clan. |
I-set | V-set | Immunoglobulin I-set (intermediate) domain. I-set and V-set are of same clan. | Immunoglobulin V-set (variable) domain. |
EGF_CA | EGF | Calcium binding EGF domain. | EGF-like protein. Both are of same clan. |
Hydrolase | E1-E2_ATPase | Haloacid dehalogenase-like hydrolase. Catalytic activity. Metabolic process | Hydrolase activity. ATP binding. |
Radical_SAM | Mob_synth_C | Catalytic activity; iron-sulfur cluster binding. | Molybdenum cofactor synthesis C. iron, sulfur cluster binding |
Aconitase | Aconitase_C | Aconitase hydratase. Lyase activity. | Aconitase hydratase. Hydro-lyase activity. |
Filament | Filament_head | Intermediate filament protein. Structural molecule activity | Head region of intermediate filaments. |
CNH | Pkinase | Citron and Citron kinase. Small GTPase regulator activity. | Protein kinase activity. ATP binding. |
PSI | Sema | Plexin repeat. Membrane. Receptor activity | Semaphorins. Secreted and transmembrane proteins. |
GTP_EFTU_D2 | GTP_EFTU | Elongation factor | GTP binding. Elongation factor |
PARP | WWE | Poly(ADP-ribose) polymerase. Catalyses covalent attachment of ADP-ribose to DNA binding proteins | Mediates protein-protein interactions in ubiquitin and ADP ribose conjugation system. |
Sushi | An_peroxidase | Complement control protein (CCP) modules, or short consensus repeats (SCR). Complement and adhesion | Animal haem peroxidase. Peroxidase activity. |
PH | Oxysterol_BP | pleckstrin homology. Intracellular signaling/constituent of cytoskeleton | Oxysterol binding protein. Steroid metabolic process |
Ank | KH_1 | Ankyrin repeat. Protein-protein interaction | K homology domain. RNA binding |
GON | TSP_1 | Proteinaceous extracellular matrix. Zinc ion binding. Metalloendopeptidase activitiy. | Thrombospondin type 1 domain. Cell adhesion |
Thioredoxin | DnaJ | Participates in redox reactions. | Heat shock protein binding |
Collagen | EMI | Collagen triple helix repeat. Phosphate transport process. Connective tissue structures. | EMI domain. Participates in multimerization |
HECT | RCC1 | HECT-domain (ubiquitin-transferase) Homologous to the E6-AP Carboxyl terminus. Ubiquitin-protein ligase; protein modification process. | Regulator of chromose condensation. Acts as a guanine-nucleotide dissociation simulator (GDS) |