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Table 1 The top 10 most conserved avoided codon pairs in the organisms studied

From: Preferred and avoided codon pairs in three domains of life

12 ↓ codon pairs % log2(obs/exp) A – B type
   ORFeome (A) genome (B)   
UUCGCA 86 -0.81 -0.86 0.05 6A
GGGGGU 83 -1.12 -0.43 -0.69 8A
UUCGAA 82 -0.76 -0.75 -0.01 6A
CUUAUG 79 -0.92 -0.63 -0.29 1A
GCUAUG 76 -0.76 -0.28 -0.48 1A
ACUAUG 73 -0.71 -0.21 -0.50 1A
GUUAGC 73 -0.92 -0.52 -0.40 1A
CUUAGU 73 -0.94 -0.83 -0.11 1A
UUCGCG 72 -0.84 -0.56 -0.28 3A
GUUAUG 72 -0.71 -0.30 -0.41 1A
  1. Codon pairs containing out-frame UAA or UAG triplets on the sense and/or antisense strand are marked in bold. The observed/expected ratios in logarithmic scale for each codon pair in the ORFeome and genome are shown. % – the percentage of organisms in which the codon pair is significantly avoided. A – B – difference between log2 (obs/exp) ratios in the ORFeome and the genome. A – B < 0 represents a stronger effect on the ORFeome level. For the avoided pattern types see Table 2. For the full lists of codon pairs avoided in at least 50% of the organisms studied see [additional file 1].