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Table 2 Effect of cichoric acid on gene expression in human iDCs

From: Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells

    Fold Change
Gene Name Common Name Accession No Treatment/Control
    (From 18 to 2.6-fold)
(A) Up-regulated at 4 h post-treatment
discs, large (Drosophila) homolog 1 DLG1 NM_004087 18.24
pre-B-cell leukemia transcription factor 2 PBX2 NM_002586 6.45
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein ID4 NM_001546 4.22
contactin associated protein-like 2 CNTNAP2 NM_014141 4.00
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54 kDa) DDX6 NM_004397 3.74
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 GNAI1 NM_002069 3.66
tropomodulin 3 (ubiquitous) TMOD3 NM_014547 3.60
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) TFPI NM_006287 3.13
tolloid-like 1 TLL1 NM_012263 3.09
RAB3 GTPase-activating protein RAB3GAP XM_040048 3.08
histone 1, H2al HIST1H2AL NM_003511 3.07
solute carrier family 4, sodium bicarbonate cotransporter, member 7 SLC4A7 NM_003615 3.00
fibulin 1 FBLN1 NM_006486 2.97
cytochrome P450, family 2, subfamily C, polypeptide 8 CYP2C8 NM_030878 2.86
peptidyl-prolyl isomerase G (cyclophilin G) PPIG NM_004792 2.80
Nijmegen breakage syndrome 1 (nibrin) NBS1 AK001017 2.76
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8 kDa NDUFB2 NM_004546 2.71
cytosolic ovarian carcinoma antigen 1 COVA1 NM_006375 2.69
zinc finger protein 305 ZNF305 NM_014724 2.67
platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30 kDa PAFAH1B2 NM_002572 2.60
Down-regulated at 4 h post-treatment (From 0.23 to 0.45-fold)
glycerol kinase GK NM_000167 0.23
SMC4 structural maintenance of chromosomes 4-like 1 (yeast) SMC4L1 AL136877 0.31
ATPase, Ca+2 transporting, type 2C, member 1 ATP2C1 AB037768 0.36
megakaryocyte-associated tyrosine kinase MATK NM_002378 0.37
ubiquitin specific protease 24 USP24 XM_165973 0.37
SEC24 related gene family, member D (S. cerevisiae) SEC24D NM_014822 0.38
talin 1 TLN1 NM_006289 0.39
methionyl aminopeptidase 2 METAP2 NM_006838 0.39
protein kinase, cAMP-dependent, regulatory, type II, beta PRKAR2B NM_002736 0.42
endothelial differentiation, G-protein-coupled receptor, 2 EDG2 NM_001401 0.42
integrin, beta 8 ITGB8 NM_002214 0.42
uridine monophosphate synthetase UMPS NM_000373 0.42
ribosomal protein L13 RPL13 AA789278 0.43
DNA cross-link repair 1B DCLRE1B NM_022836 0.43
chloride channel, calcium activated, family member 2 CLCA2 NM_006536 0.43
caspase 2, apoptosis-related cysteine protease CASP2 NM_032982 0.44
apoptotic chromatin condensation inducer in the nucleus ACINUS NM_014977 0.45
peptidoglycan recognition protein-I-beta precursor PGLYRPIBETA NM_020393 0.45
    Fold Change
Gene Name Common Name Accession No Treatment/Control
    (From 18.9 to 5.4-fold)
(B) Up-regulated at 24 h post-treatment  
Zinc finger protein 229 ZNF228 AC084239 18.93
adaptor-related protein complex 4, sigma 1 subunit AP4S1 NM_007077 14.10
chromosome 8 open reading frame 17 C8ORF17 NM_020237 12.13
DKFZP566K023 protein DKFZP566K023 NM_015485 11.07
glycine receptor, alpha 1 GLRA1 NM_000171 10.81
frizzled homolog 3 (Drosophila) FZD3 NM_017412 10.31
secreted frizzled-related protein 1 SFRP1 NM_003012 10.11
chorea acanthocytosis CHAC AB023203 9.56
actin, alpha, cardiac muscle ACTC NM_005159 9.51
tripartite motif-containing 45 TRIM45 NM_025188 8.26
phosphodiesterase 4D, cAMP-specific PDE4D AF012073 8.23
v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog KRAS2 NM_004985 7.79
absent in melanoma 1-like AIM1L NM_017977 6.79
protein phosphatase 2, regulatory subunit B, beta isoform PPP2R2B NM_004576 6.75
integral membrane protein 2A ITM2A AL021786 6.43
cannabinoid receptor 1 (brain) CNR1 U73304 6.09
cholinergic receptor, nicotinic, alpha polypeptide 5 CHRNA5 NM_000745 6.02
SMC5 structural maintenance of chromosomes 5-like 1 (yeast) SMC5L1 NM_015110 5.78
protein kinase, cAMP-dependent, regulatory, type I, beta PRKAR1B AL833563 5.77
ATP-binding cassette, sub-family A (ABC1), member 1 ABCA1 AF285167 5.36
Down-regulated at 24 h post-treatment (From 0.13 to 0.37-fold)
interferon-inducible protein p78 (mouse) MX1 NM_002462 0.13
interferon-induced protein 44 IFI44 NM_006417 0.16
interferon, alpha-inducible protein (clone IFI-15K) G1P2 NM_005101 0.20
protein kinase, interferon-inducible double stranded RNA dependent PRKR NM_002759 0.21
2'-5'-oligoadenylate synthetase 2, 69/71 kDa OAS2 NM_016817 0.24
BCL2-like 11 (apoptosis facilitator) BCL2L11 NM_006538 0.28
methionyl aminopeptidase 2 METAP2 NM_006838 0.28
signal transducer and activator of transcription 1 (91 kDa) STAT1 NM_007315 0.29
myxovirus (influenza virus) resistance 2 (mouse) MX2 NM_002463 0.30
SP110 nuclear body protein SP110 AF280094 0.30
sialoadhesin SN NM_023068 0.30
mitochondrial ribosomal protein S14 MRPS14 NM_022100 0.31
similar to S. cerevisiae SSM4 TEB4 NM_005885 0.31
XIAP associated factor-1 HSXIAPAF1 NM_017523 0.33
SP110 nuclear body protein SP110 NM_004509 0.35
retinitis pigmentosa 2 (X-linked recessive) RP2 NM_006915 0.36
zinc finger protein 83 (HPF1) ZNF83 NM_018300 0.36
zinc finger antiviral protein ZAP NM_020119 0.36
TIA1 cytotoxic granule-associated RNA binding protein TIA1 NM_022173 0.38
RAN binding protein 9 RANBP9 NM_005493 0.38
  1. Top 20 genes up- or down-regulated in human immature DCs in response to treatment with cichoric acid (50 g/ml) of Echinacea purpurea for 4 h (A) by fold change in expression.