Table 2 Effect of cichoric acid on gene expression in human iDCs

(A) Up-regulated at 4 h post-treatment

discs, large (Drosophila) homolog 1

pre-B-cell leukemia transcription factor 2

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

contactin associated protein-like 2

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54 kDa)

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

tropomodulin 3 (ubiquitous)

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

tolloid-like 1

RAB3 GTPase-activating protein

histone 1, H2al

solute carrier family 4, sodium bicarbonate cotransporter, member 7

fibulin 1

cytochrome P450, family 2, subfamily C, polypeptide 8

peptidyl-prolyl isomerase G (cyclophilin G)

Nijmegen breakage syndrome 1 (nibrin)

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8 kDa

cytosolic ovarian carcinoma antigen 1

zinc finger protein 305

platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30 kDa

Down-regulated at 4 h post-treatment

glycerol kinase

SMC4 structural maintenance of chromosomes 4-like 1 (yeast)

ATPase, Ca⁺² transporting, type 2C, member 1

megakaryocyte-associated tyrosine kinase

ubiquitin specific protease 24

SEC24 related gene family, member D (S. cerevisiae)

talin 1

methionyl aminopeptidase 2

protein kinase, cAMP-dependent, regulatory, type II, beta

endothelial differentiation, G-protein-coupled receptor, 2

integrin, beta 8

uridine monophosphate synthetase

ribosomal protein L13

DNA cross-link repair 1B

chloride channel, calcium activated, family member 2

caspase 2, apoptosis-related cysteine protease

apoptotic chromatin condensation inducer in the nucleus

peptidoglycan recognition protein-I-beta precursor

Gene Name

(B) Up-regulated at 24 h post-treatment

Zinc finger protein 229

adaptor-related protein complex 4, sigma 1 subunit

chromosome 8 open reading frame 17

DKFZP566K023 protein

glycine receptor, alpha 1

frizzled homolog 3 (Drosophila)

secreted frizzled-related protein 1

chorea acanthocytosis

actin, alpha, cardiac muscle

tripartite motif-containing 45

phosphodiesterase 4D, cAMP-specific

v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog

absent in melanoma 1-like

protein phosphatase 2, regulatory subunit B, beta isoform

integral membrane protein 2A

cannabinoid receptor 1 (brain)

cholinergic receptor, nicotinic, alpha polypeptide 5

SMC5 structural maintenance of chromosomes 5-like 1 (yeast)

protein kinase, cAMP-dependent, regulatory, type I, beta

ATP-binding cassette, sub-family A (ABC1), member 1

Down-regulated at 24 h post-treatment

interferon-inducible protein p78 (mouse)

interferon-induced protein 44

interferon, alpha-inducible protein (clone IFI-15K)

protein kinase, interferon-inducible double stranded RNA dependent

2'-5'-oligoadenylate synthetase 2, 69/71 kDa

BCL2-like 11 (apoptosis facilitator)

methionyl aminopeptidase 2

signal transducer and activator of transcription 1 (91 kDa)

myxovirus (influenza virus) resistance 2 (mouse)

SP110 nuclear body protein

sialoadhesin

mitochondrial ribosomal protein S14

similar to S. cerevisiae SSM4

XIAP associated factor-1

SP110 nuclear body protein

retinitis pigmentosa 2 (X-linked recessive)

zinc finger protein 83 (HPF1)

zinc finger antiviral protein

TIA1 cytotoxic granule-associated RNA binding protein

RAN binding protein 9