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Table 3 Genes showing overlapping up- or down-regulation in iDCs after treatment with [BF/S+L/Ep] or cichoric acid

From: Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells

Genes up-regulated

Genebank

Fold Change in Treatment with [BF/S+L/Ep] (From 23.9 to 2.7-fold)

Fold Change in Treatment with Cichoric Acid (From 14 to 3.1-fold)

adaptor-related protein complex 4

NM_007077

23.91

14.10

secreted frizzled-related protein 1

NM_003012

10.17

10.11

cholinergic receptor

NM_000745

9.95

6.02

chorea acanthocytosis

AB023203

9.91

9.56

tripartite motif-containing 45

NM_025188

8.34

8.26

zinc finger protein (ZFD25)

NM_016220

5.27

5.35

SUMO-1-specific protease

NM_015571

5.02

4.56

nuclear respiratory factor 1

NM_005011

4.97

3.39

pleckstrin homology-like domain

NM_007350

4.79

3.36

protein phosphatase 2

NM_004576

4.56

6.75

chromosome 19 open reading frame 2

NM_003796

3.91

3.27

SMC5 structural maintenance of chromosomes 5-like 1 (yeast)

NM_015110

3.87

5.78

myeloid/lymphoid or mixed-lineage leukemia

NM_004641

3.70

5.34

aryl hydrocarbon receptor interacting protein-like 1

NM_014336

3.60

3.70

left-right determination, factor B

NM_020997

3.53

4.14

ATP-binding cassette, sub-family A

NM_005502

3.35

5.36

RBP1-like protein

NM_016374

3.07

3.26

solute carrier family 26, member 10

NM_133489

2.89

3.05

insulin induced gene 1

NM_005542

2.87

3.12

ceroid-lipofuscinosis, neuronal 8

NM_018941

2.72

3.10

Genes down-regulated

Gene bank

(From 0.08 to 0.38-fold)

(From 0.13 to 0.4-fold)

Interferon-inducible protein p78 (mouse)

NM_002462

0.09

0.13

Interferon-inducible protein 44

NM_006417

0.16

0.16

Interferon, alpha-inducible protein (clone IFI-15K)

NM_005101

0.19

0.20

Mitochondrial ribosomal protein S14

NM_022100

0.27

0.31

2'-5'-oligoadanylate synthetase 2, 69/71 kDa

NM_016817

0.27

0.24

Myxovirus (influenza virus) resistance 2 (mouse)

NM_002463

0.29

0.30

XIAP associated factor-1

NM_017523

0.30

0.33

SP110 nuclear body protein

NM_080424

0.33

0.35

Signal transducer and activator of transcription 1, (91 kDa)

NM_007315

0.33

0.29

zinc finger antiviral protein

NM_020119

0.34

0.36

Solute carrier family 35

NM_012243

0.36

0.38

  1. Human immature DCs were treated for 24 h with test samples and assayed for differential gene expression.