Skip to main content

Table 2 Microsatellite types with a significant difference in frequency either between hot and non-hot IGRs, or hot and non-hot ORFs, in the S. cerevisiae genome. Significance was inferred where p < 0.0026, with the level of alpha adjusted for 19 independent classes of repeat using Bonferroni's correction. The Mann-Whitney U Test or T Test was used, depending whether samples were normally distributed. The e value denotes the number of bases in any part of a repeat within which no more than one mismatch was allowed with respect to the consensus motif. A lower e value therefore results in the detection of more imperfect repeats.

From: High frequency of microsatellites in S. cerevisiae meiotic recombination hotspots

Repeat type IGRs ORFs
Motif length Copy number Mis-matches allowed Mean per kb freq. Freq. ratio (hot/non hot) P value Mean per kb freq. Freq. ratio (hot/non hot) P value
    Hot Non hot    Hot Non hot   
1 (A) 3 to 5 perfect 35.0 39.9 0.88 < 0.0001 29.2 36.1 0.81 < 0.0001
   e = 10 34.3 39.4 0.87 < 0.0001 29.1 36.0 0.81 < 0.0001
   e = 6 31.8 36.7 0.87 < 0.0001 28.0 34.7 0.81 < 0.0001
  6+ perfect 5.42 4.61 1.17 < 0.0001 0.981 1.64 0.60 < 0.0001
   e = 10 5.24 4.50 1.16 < 0.0001 0.978 1.64 0.60 < 0.0001
   e = 6 6.12 5.53 1.11 0.00173 1.28 2.13 0.60 < 0.0001
  14+ perfect 0.418 0.171 2.45 < 0.0001 0.0134 0.00733 1.83 n/s
   e = 10 0.733 0.311 2.36 < 0.0001 0.0182 0.0166 1.10 n/s
   e = 6 0.854 0.377 2.26 < 0.0001 0.0218 0.0271 0.80 n/s
1 (G) 3 to 5 perfect 9.18 7.25 1.27 < 0.0001 12.9 10.1 1.28 < 0.0001
   e = 10 9.16 7.24 1.27 < 0.0001 12.9 10.1 1.28 < 0.0001
   e = 6 8.89 7.13 1.25 < 0.0001 12.6 9.93 1.27 < 0.0001
  6+ e = 6 0.160 0.0931 1.72 0.00124 0.135 0.0798 1.69 n/s
  14+ perfect 0.0035 0.000725 4.83 0.00179 0 0 n/a n/a
   e = 10 0.0035 0.000725 4.83 0.00179 0 0 n/a n/a
   e = 6 0.0035 0.000725 4.83 0.00179 0 0 n/a n/a
2 3 to 5 perfect 4.67 3.96 1.18 < 0.0001 1.82 1.74 1.05 n/s
   e = 10 4.34 3.68 1.18 0.000266 1.78 1.71 1.04 n/s
   e = 6 6.17 5.52 1.12 0.000234 3.18 3.14 1.01 n/s
  6+ perfect 0.368 0.196 1.88 0.000248 0.0405 0.00572 7.09 n/s
   e = 10 0.599 0.356 1.68 < 0.0001 0.0720 0.0229 3.14 n/s
   e = 6 0.797 0.529 1.51 < 0.0001 0.109 0.0398 2.73 n/s
  10+ perfect 0.158 0.0606 2.62 n/s 0.0163 0.00173 9.44 < 0.0001
   e = 10 0.221 0.0931 2.38 0.00164 0.0207 0.00275 7.53 < 0.0001
   e = 6 0.252 0.109 2.32 0.00132 0.0159 0.00584 2.72 < 0.0001
6 6+ e = 6 0.00552 0.00341 1.62 n/s 0.0135 0.000877 15.40 < 0.0001