Figure 1

Resolving power curves for detection of one-copy deletions with 50-mer oligonucleotides. The open circles show the results from resolving power calculations for one-copy deletions, in other words, the logarithm of the expected p-value for a deletion is shown as a function of the number of probes affected by the copy-number aberration. The solid (dashed) lines are linear regressions of the resolving power calculations in C. elegans (human), with their slope being provided in the legends. Red data points and lines correspond to calculations using any oligonucleotide on the arrays without further filtering while the green lines and data points correspond to resolving power calculations after selecting the oligonucleotides with our standard filters as described in the Methods section.