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Table 3 Metabolism-related hepatic transcripts exhibiting differential expression between the two dietary groups (HE vs LE)1

From: Changes induced by dietary energy intake and divergent selection for muscle fat content in rainbow trout (Oncorhynchus mykiss), assessed by transcriptome and proteome analysis of the liver

Biological function HE/LE ratio ANOVA SAM
GenBank Acc. N° Best-hit Swiss-Prot description L line F line P-value FDR cut off
Lipid metabolism (40.5%)
CA344881 Trifunctional enzyme subunit alpha, mitochondrial precursor -1.3 -1.4 < 5.10-4 0
BX885839 Acetyl-CoA acetyltransferase, cytosolic (ACAT2) -1.5 -2.1 < 10-3 0
BX861803 Phosphatidylinositol-glycan biosynthesis class F protein (PIG-F) -1.3 -1.2 0.003 0.1
BX080468 Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor -1.3 -1.1 0.004 0.15
Fatty acid desaturation (2.7%)
CA371783 putative delta-6 fatty acid desaturase (Δ6-FAD) -1.9 -2.0 0.005 0.05
Lipid transport (10.8%)
CU069821 Acetyl coenzyme A binding protein (ACBP) -2.1 -1.9 < 5.10-5 0
BX078901 Vitellogenin precursor (VTG) -1.2 -1.4 < 10-3 0.05
CU069693 Heart-type fatty acid binding protein (H-FABP) -1.4 -1.5 < 10-3 0
BX298066 Heart-type fatty acid binding protein (H-FABP) -1.6 -1.5 0.004 0.05
Cholesterol metabolism (16.2%)
BX875391 Probable ergosterol biosynthetic protein 28 (ERG28) -1.8 -2.3 < 5.10-6 0
CU069450 24-dehydrocholesterol reductase precursor (DHC24) -1.8 -2.7 < 5.10-4 0
CA344888 Retinol dehydrogenase 12 (RDH12) -1.2 -2.0 0.003 0.05
CA382526 Orphan nuclear receptor NR1D2 (Rev-erbβ) -1.2 -1.2 0.004 0.15
CA377380 C-4 methylsterol oxidase (ERG25) -1.2 1.5 0.006 0.1
CU069541 Cholesteryl ester transfer protein precursor (CETP) -1.4 -1.2 0.006 0.15
Generation of precursor metabolites and energy (13.5%)
BX084640 6-phosphogluconate dehydrogenase, decarboxylating (6-PGD) -1.4 -2.2 < 5.10-4 0
BX080843 Ubiquinol-cytochrome c reductase complex 9.5 kDa protein -1.4 -1.3 < 5.10-4 0
BX886412 ATP synthase subunit alpha, mitochondrial precursor (ATPA) -1.1 -1.4 0.001 0.1
CA377924 Vacuolar ATP synthase subunit δ (V-ATPase δ subunit) -1.2 -1.4 0.002 0.05
CU067427 Pyruvate carboxylase, mitochondrial precursor -1.2 -1.1 0.008 0.15
Carbohydrate metabolism (2.7%)
CA383037 Solute carrier family 2, facilitated glucose transporter member 11 -1.7 -1.6 < 10-4 0
Amino-acid derivative metabolism (8.1%)
CU068986 Acetylcholinesterase precursor (EC 3.1.1.7) (AChE) -1.7 -1.7 < 5.10-4 0
CU070780 D-3-phosphoglycerate dehydrogenase (3-PGDH) -1.4 -1.2 0.002 0.05
CU067302 Cystathionine gamma-lyase (CGL) -1.4 -1.0 0.008 0.15
Protein folding/synthesis/breakdown (16.2%)
CU072931 Tripeptidyl-peptidase 2 -1.3 -1.7 < 10-4 0
CA362332 Ubiquitin-conjugating enzyme E2 E1 (UB2E1) -1.3 -1.3 0.002 0.15
CU068585 STIP1 homology and U box-containing protein 1 -1.4 -1.5 0.003 0.05
BX307921 McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin -1.2 -1.4 0.005 0.15
CA342952 Proteasome subunit beta type 7 precursor (PSB7) -1.2 -1.1 0.01 0.15
CU066852 F-box/WD repeat protein 2 -1.4 -1.1 0.03 0.1
Xenobiotic and oxidant metabolism (10.8%)
CU070243 Peptide methionine sulfoxide reductase -1.3 -1.3 10-3 0.05
CU071592 Cytochrome P450 2J2 (Arachidonic acid epoxygenase) 1.9 2.2 0.003 0.1
BX081745 Matrix metalloproteinase-16 precursor 1.9 1.6 0.003 0.15
BX308633 Stress-activated protein kinase 3 (MK12) -1.2 -1.3 0.008 0.15
Purine metabolism (8.1%)
CU073027 Ectonucleoside triphosphate diphosphohydrolase 1 -1.3 -1.1 < 10-3 0.05
CA363765 Adenylate kinase isoenzyme 2, mitochondrial -1.3 -1.2 < 10-4 0.05
CA371563 Ribonucleoside-diphosphate reductase large subunit 2.6 3.9 0.001 0.05
  1. 1 According to both ANOVA (p < 0.01) and SAM (FDR < 0.15) analysis