Table 3 Metabolism-related hepatic transcripts exhibiting differential expression between the two dietary groups (HE vs LE)1
Biological function | HE/LE ratio | ANOVA | SAM | ||
|---|---|---|---|---|---|
GenBank Acc. N° | Best-hit Swiss-Prot description | L line | F line | P-value | FDR cut off |
Lipid metabolism (40.5%) | |||||
CA344881 | Trifunctional enzyme subunit alpha, mitochondrial precursor | -1.3 | -1.4 | < 5.10-4 | 0 |
BX885839 | Acetyl-CoA acetyltransferase, cytosolic (ACAT2) | -1.5 | -2.1 | < 10-3 | 0 |
BX861803 | Phosphatidylinositol-glycan biosynthesis class F protein (PIG-F) | -1.3 | -1.2 | 0.003 | 0.1 |
BX080468 | Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor | -1.3 | -1.1 | 0.004 | 0.15 |
Fatty acid desaturation (2.7%) | |||||
CA371783 | putative delta-6 fatty acid desaturase (Δ6-FAD) | -1.9 | -2.0 | 0.005 | 0.05 |
Lipid transport (10.8%) | |||||
CU069821 | Acetyl coenzyme A binding protein (ACBP) | -2.1 | -1.9 | < 5.10-5 | 0 |
BX078901 | Vitellogenin precursor (VTG) | -1.2 | -1.4 | < 10-3 | 0.05 |
CU069693 | Heart-type fatty acid binding protein (H-FABP) | -1.4 | -1.5 | < 10-3 | 0 |
BX298066 | Heart-type fatty acid binding protein (H-FABP) | -1.6 | -1.5 | 0.004 | 0.05 |
Cholesterol metabolism (16.2%) | |||||
BX875391 | Probable ergosterol biosynthetic protein 28 (ERG28) | -1.8 | -2.3 | < 5.10-6 | 0 |
CU069450 | 24-dehydrocholesterol reductase precursor (DHC24) | -1.8 | -2.7 | < 5.10-4 | 0 |
CA344888 | Retinol dehydrogenase 12 (RDH12) | -1.2 | -2.0 | 0.003 | 0.05 |
CA382526 | Orphan nuclear receptor NR1D2 (Rev-erbβ) | -1.2 | -1.2 | 0.004 | 0.15 |
CA377380 | C-4 methylsterol oxidase (ERG25) | -1.2 | 1.5 | 0.006 | 0.1 |
CU069541 | Cholesteryl ester transfer protein precursor (CETP) | -1.4 | -1.2 | 0.006 | 0.15 |
Generation of precursor metabolites and energy (13.5%) | |||||
BX084640 | 6-phosphogluconate dehydrogenase, decarboxylating (6-PGD) | -1.4 | -2.2 | < 5.10-4 | 0 |
BX080843 | Ubiquinol-cytochrome c reductase complex 9.5 kDa protein | -1.4 | -1.3 | < 5.10-4 | 0 |
BX886412 | ATP synthase subunit alpha, mitochondrial precursor (ATPA) | -1.1 | -1.4 | 0.001 | 0.1 |
CA377924 | Vacuolar ATP synthase subunit δ (V-ATPase δ subunit) | -1.2 | -1.4 | 0.002 | 0.05 |
CU067427 | Pyruvate carboxylase, mitochondrial precursor | -1.2 | -1.1 | 0.008 | 0.15 |
Carbohydrate metabolism (2.7%) | |||||
CA383037 | Solute carrier family 2, facilitated glucose transporter member 11 | -1.7 | -1.6 | < 10-4 | 0 |
Amino-acid derivative metabolism (8.1%) | |||||
CU068986 | Acetylcholinesterase precursor (EC 3.1.1.7) (AChE) | -1.7 | -1.7 | < 5.10-4 | 0 |
CU070780 | D-3-phosphoglycerate dehydrogenase (3-PGDH) | -1.4 | -1.2 | 0.002 | 0.05 |
CU067302 | Cystathionine gamma-lyase (CGL) | -1.4 | -1.0 | 0.008 | 0.15 |
Protein folding/synthesis/breakdown (16.2%) | |||||
CU072931 | Tripeptidyl-peptidase 2 | -1.3 | -1.7 | < 10-4 | 0 |
CA362332 | Ubiquitin-conjugating enzyme E2 E1 (UB2E1) | -1.3 | -1.3 | 0.002 | 0.15 |
CU068585 | STIP1 homology and U box-containing protein 1 | -1.4 | -1.5 | 0.003 | 0.05 |
BX307921 | McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin | -1.2 | -1.4 | 0.005 | 0.15 |
CA342952 | Proteasome subunit beta type 7 precursor (PSB7) | -1.2 | -1.1 | 0.01 | 0.15 |
CU066852 | F-box/WD repeat protein 2 | -1.4 | -1.1 | 0.03 | 0.1 |
Xenobiotic and oxidant metabolism (10.8%) | |||||
CU070243 | Peptide methionine sulfoxide reductase | -1.3 | -1.3 | 10-3 | 0.05 |
CU071592 | Cytochrome P450 2J2 (Arachidonic acid epoxygenase) | 1.9 | 2.2 | 0.003 | 0.1 |
BX081745 | Matrix metalloproteinase-16 precursor | 1.9 | 1.6 | 0.003 | 0.15 |
BX308633 | Stress-activated protein kinase 3 (MK12) | -1.2 | -1.3 | 0.008 | 0.15 |
Purine metabolism (8.1%) | |||||
CU073027 | Ectonucleoside triphosphate diphosphohydrolase 1 | -1.3 | -1.1 | < 10-3 | 0.05 |
CA363765 | Adenylate kinase isoenzyme 2, mitochondrial | -1.3 | -1.2 | < 10-4 | 0.05 |
CA371563 | Ribonucleoside-diphosphate reductase large subunit | 2.6 | 3.9 | 0.001 | 0.05 |