Figure 3
From: Histone deacetylase inhibitors: A new mode for inhibition of cholesterol metabolism
(A)Hierarchical clustering of HepG2 cells treated with ethanol or TSA shows that the majority of genes are down regulated (green) by TSA treatment in contrast with the current paradigm of the role of HDACs in gene repression. Gene Ontology analysis of the terms related too "biological process" (p-value < 0.05) shows a significant difference in the genes being up-regulated (B) or down-regulated (C) by TSA. The down regulation of metabolic processes includes cholesterol, lipid and fatty acid metabolism.