Table 2 The temporal pattern of genes down-regulated with IGF-1 treatment

1420019_at

Tspan8

Tetraspanin 8

0.41

1438317_a_at

Endog

Endonuclease G

0.44

1427298_at

Dnm3os

Dynamin 3, opposite strand

0.46

1456078_x_at

Tubb2c

Tubulin, beta 2c

0.46

1427543_s_at

Ube1y1

Ubiquitin-activating enzyme E1, Chr X

0.47

1438403_s_at

Ramp2

Receptor (calcitonin) activity modifying protein 2

0.48

Genes down-regulated at 1 & 2 hrs

1415996_at

Txnip

Thioredoxin interacting protein

0.47

Genes down-regulated at 1 & 4 hrs

1442744_at

Rbm39

RNA binding motif protein 39

0.45

Genes down-regulated at 1, 2 & 4 hrs

1448830_at

Dusp1

Dual specificity phosphatase 1

0.35

1416630_at

Ib3

Inhibitor of DNA binding 3

0.49

Genes (23) down-regulated at 2 hrs only

1422474_at

Pde4b

Phosphodiesterase 4B, cAMP specific

0.29

1435872_at

Pim1

Proviral integration site 1

0.32

1416488_at

Ccng2

Cyclin G2

0.35

1422473_at

Pde4b

Phosphodiesterase 4B, cAMP specific

0.36

1427005_at

Plk2

Polo-like kinase 2

0.37

1456569_x_at

Gsn

Gelsolin

0.39

1433668_at

Pnrc1

Proline-rich nuclear receptor coactivator 1

0.41

1419080_at

Gdnf

Glial cell line derived neurotrophic factor

0.42

1416286_at

Rgs4

Regulator of G-protein signaling 4

0.44

1460009_at

Ier5

Immediate early response 5

0.45

1422195_s_at

Tbx15

T-box 15

0.46

1448364_at

Ccng2

Cyclin G2

0.47

1416619_at

Rik

RIKEN 4632428N05 gene

0.47

1450741_at

Stau1

Staufen (RNA binding protein) homolog 1

0.47

1427479_at

BB287469

Eukaryotic translation initiation factor1A, predicted

0.48

1434940_x_at

Rgs19

Regulator of G-protein signaling 19

0.48

1437101_at

Lats2

LATS2B, alternatively spliced

0.49

1452604_at

Stard13

Serologically defined colon cancer antigen 13

0.49

1456528_x_at

Ncl

Nucleolin

0.49

1439441_x_at

Lats1

Large tumor suppressor 2

0.49

1427130_x_at

Rik

RIKEN 1700021K02 gene

0.49

1451731_at

Abc1

ATP-binding cassette, sub-family A, member 3

0.49

1453355_at

Wnk2

WNK lysine deficient protein kinase 2

0.50