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Table 2 The temporal pattern of genes down-regulated with IGF-1 treatment

From: Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts

Affy. Id. Symbol Genes down-regulated at 1 hr only Fold Change
1420019_at Tspan8 Tetraspanin 8 0.41
1438317_a_at Endog Endonuclease G 0.44
1427298_at Dnm3os Dynamin 3, opposite strand 0.46
1456078_x_at Tubb2c Tubulin, beta 2c 0.46
1427543_s_at Ube1y1 Ubiquitin-activating enzyme E1, Chr X 0.47
1438403_s_at Ramp2 Receptor (calcitonin) activity modifying protein 2 0.48
   Genes down-regulated at 1 & 2 hrs  
1415996_at Txnip Thioredoxin interacting protein 0.47
   Genes down-regulated at 1 & 4 hrs  
1442744_at Rbm39 RNA binding motif protein 39 0.45
   Genes down-regulated at 1, 2 & 4 hrs  
1448830_at Dusp1 Dual specificity phosphatase 1 0.35
1416630_at Ib3 Inhibitor of DNA binding 3 0.49
   Genes (23) down-regulated at 2 hrs only  
1422474_at Pde4b Phosphodiesterase 4B, cAMP specific 0.29
1435872_at Pim1 Proviral integration site 1 0.32
1416488_at Ccng2 Cyclin G2 0.35
1422473_at Pde4b Phosphodiesterase 4B, cAMP specific 0.36
1427005_at Plk2 Polo-like kinase 2 0.37
1456569_x_at Gsn Gelsolin 0.39
1433668_at Pnrc1 Proline-rich nuclear receptor coactivator 1 0.41
1419080_at Gdnf Glial cell line derived neurotrophic factor 0.42
1416286_at Rgs4 Regulator of G-protein signaling 4 0.44
1460009_at Ier5 Immediate early response 5 0.45
1422195_s_at Tbx15 T-box 15 0.46
1448364_at Ccng2 Cyclin G2 0.47
1416619_at Rik RIKEN 4632428N05 gene 0.47
1450741_at Stau1 Staufen (RNA binding protein) homolog 1 0.47
1427479_at BB287469 Eukaryotic translation initiation factor1A, predicted 0.48
1434940_x_at Rgs19 Regulator of G-protein signaling 19 0.48
1437101_at Lats2 LATS2B, alternatively spliced 0.49
1452604_at Stard13 Serologically defined colon cancer antigen 13 0.49
1456528_x_at Ncl Nucleolin 0.49
1439441_x_at Lats1 Large tumor suppressor 2 0.49
1427130_x_at Rik RIKEN 1700021K02 gene 0.49
1451731_at Abc1 ATP-binding cassette, sub-family A, member 3 0.49
1453355_at Wnk2 WNK lysine deficient protein kinase 2 0.50
  1. The temporal pattern of genes down-regulated in mouse myoblasts following IGF-1 treatment is tabulated based on their Venn distribution. Shown are genes down-regulated at: 1 hr only; 1 & 2 hrs; at 1 & 4 hrs; 1, 2 & 4 hrs and 2 hrs only (Please see Additional file 2 for genes down-regulated at 2 & 4 hrs and 4 hrs only).
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BMC Genomics

ISSN: 1471-2164

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