|
Affy. Id.
|
Symbol
|
Genes up-regulated at 4 hrs
|
Fold Change
|
|---|
|
1425326_at
|
Acyl
|
ATP citrate lyase *
|
2.7
|
|
1418911_s_at
|
Acas1
|
Acyl CoA synthetase *
|
1.9
|
|
1427595_at
|
Acat1
|
Acetyl-CoA carboxylase
|
N/C
|
|
1423828_at
|
Fas
|
Fatty acid synthase
|
2.3
|
|
1451457_at
|
Sc5dl
|
Delta-5 desaturase
|
2.0
|
|
1415824_at
|
Scd1
|
Steroyl CoA desaturase
|
1.8
|
|
1417404_at
|
Evol6
|
Elongation of Long chain FA-6
|
2.3
|
- The genes involved in fatty acid biosynthesis that are induced by about two-fold or greater levels at 4 hours are listed. Only a selective number of fatty acid genes are induced by IGF-1. Acetyl-CoA carboxylase a key and rate-limiting enzyme in the pathway shows no detectable transcriptionally induction. Genes common to the fatty acid and cholesterol biosynthetic pathways (see Table 4) are indicated (*) and genes showing 'No Change' in expression levels are also listed (N/C).
