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Figure 2 | BMC Genomics

Figure 2

From: Transcriptional response of rat frontal cortex following acute In Vivo exposure to the pyrethroid insecticides permethrin and deltamethrin

Figure 2

Dose-response functions identified by PIR and SAM regression methods. Panels A-F plot dose-response functions for probe sets identified by PIR (B & E), SAM (C & F) or both regression methods (A & D) for deltamethrin (A-C) and permethrin (D-F). Only probe sets that had a Benjamini-Hochberg adjusted p-value < 0.05 for a main effect of dose in a one-way ANOVA are shown. For each probe set expression summaries for each treatment group were normalized to vehicle control and plotted as fold-change from control. The color scheme corresponds to that used in Figure 1, with green curves being detected by both PIR and SAM regression methods (A, D), blue curves being detected exclusively with the PIR method (B, E) and orange curves being detected exclusively with the SAM method (C, F). Insets on each panel are the summated results of a Dunnett's many-to-one mean contrast test performed within each probe set comparing the means of the lowest (C-L), middle (C-M) and highest (C-H) doses to the mean of vehicle treated control. y-axis is number of probe sets identified under each comparison at a significance level of p < 0.05. Note the green portion of the stacked bars in the insets are the same values in inset panels A-C and D-E, respectively.

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