Transcriptional response of rat frontal cortex following acute In Vivo exposure to the pyrethroid insecticides permethrin and deltamethrin

Table 1 Group sizes of cohorts used in this study.

^a Microarray data from Cohorts 1 & 2 were combined (n = 8/treatment group) with control values from cohorts 1 & 2 (n = 12) for dose-response analysis of permethrin and deltamethrin mediated effects, respectively. ^b Test animals in Cohort 3 were split into two dose-response studies for permethrin and deltamethrin, respectively, for qRT-PCR confirmation of gene expression changes observed during the microarray study. ^c Test animals in Cohort 4 were used for qRT-PCR time course studies. Four time points (1,3,6,9 hours: n = 8/treatment group) per compound with time matched controls (n = 8/control group). NOAEL = no observable adverse effect level; < NOAEL = less than no observable adverse effect level.

ISSN: 1471-2164