Transcriptional response of rat frontal cortex following acute In Vivo exposure to the pyrethroid insecticides permethrin and deltamethrin

Table 5 Significant Analysis of Function and Expression (SAFE) results.

Commonly enriched gene categories for both permethrin and deltamethrin^a
Category I.D. and name	size^b	DLT p-value	PERM p-value
*GO Biological Process*
GO:0048754, 'branching morophogenesis of a tube'	66	0.0171	2.00E-04
GO:0001763, 'morphogenesis of a branching structure'	67	0.0172	2.00E-04
GO:0007162, 'negative regulation of cell adhesion'	27	0.0175	0.0025
GO:0015718, 'monocarboxylic acid transport'	30	0.0051	0.0125
GO:0007498, 'mesoderm development'	57	0.0105	0.0067
*GO Cellular Component*
GO:0005954, 'Ca⁺² and calmodulin-dependent protein kinase complex'	25	0.0053	0.0146
*GO Molecular Function*
GO:0046915, 'transition metal ion transporter activity'	44	0.0026	0.0348
Enriched gene categories identified by SAFE.
Category I.D. and name	size ^b	p -value ^c
Deltamethrin
*KEGG Pathway*
KEGG:00564, 'Glycerophospholipid metabolism'	73	0.0404
KEGG:00400, 'Phenylalanine, tyrosine and tryptophan biosynthesis	12	0.0928
Permethrin
*GO Biological Process*
GO:0048754, 'branching morphogenesis of a tube'	66	0.0349
GO:0001763, 'morphogenesis of a branching structure'	67	0.0349
GO:0001569, 'patterning of blood vessels'	31	0.0406
GO:0009880, 'embryonic pattern specification'	49	0.0554
GO:0045655, 'regulation of monocyte differentiation'	32	0.0932

^a GO catergories or KEGG pathways with p < 0.05 for both test compounds using Fisher's combined p-value method to test for joint enrichment in the SAFE procedure. ^b number of Affymetrix probe sets included in GO category or KEGG pathway groupings. ^c GO categories or KEGG pathways with an adjusted p < 0.1 for SAFE method. 700 GO-BP (biological processes), 142 GO-CC (cellular component), 307 GO-MF (molecular function) and 126 KEGG pathways were examined.

ISSN: 1471-2164