Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2)

Table 2 Differentially expressed regulatory genes identified using Euclidean distance and significance analysis test

Gene	Description	Euclidean Distance^†	q-value*
SCO0379	Catalase (katA)	0.38	0.011
SCO0381	Putative glycosyl transferase	0.20	0.232
SCO0382	UDP-glucose/GDP-mannose family dehydrogenase (ugd)	0.30	0.0038
SCO0383	Hypothetical protein	0.28	0.035
SCO0736	Putative secreted protein	0.33	0.022
SCO0930	Putative lipoprotein	0.59	0.123
SCO1627	Putative ATP-GTP binding protein (rarD)	0.39	0.221
SCO1629	Conserved hypothetical protein (rarB)	0.39	0.116
SCO1630	Putative integral membrane protein (rarA)	0.35	0.144
SCO2195	Hypothetical protein	0.59	0.236
SCO2196	Putative integral membrane protein	0.33	0.053
SCO2953	Putative anti sigma factor (rsuA)	0.31	0.296
SCO2954	Putative RNA polymerase sigma factor (sigU)	0.46	0.412
SCO5147	putative ECF-subfamily sigma factor (sigE)	0.31	0.044
SCO7251	Conserved hypothetical protein	0.30	0.169
SCO7252	Putative regulatory protein	0.37	0.0038

^† Euclidean distance normalized with number of time-points. Compare with the average Euclidean distance (μ) for all genes = 0.134 and standard deviation (σ) = 0.067. Euclidean distances ≥ μ + 1.2 σ indicates significant differential expression.
*q-value from significance analysis of time-series data. Values less than 0.25 are statistically significant.

ISSN: 1471-2164