Figure 1

Examples of inconsistent genomic contexts of conserved pre-miRNAs in human, mouse and rat. Connecting lines indicate orthology. (a) Human mir-22 is located in the exon of the RefSeq gene (accession NP_116284.2), which has no annotated ortholog in mouse and rat; (b) Human and mouse miR-148b are located in the first intron of the COPZ1 transcript. The terminal 5' exon of orthologous transcript NP_001101587.1 in rat is missing, locating miR-148b upstream of NP_001101587.1; (c) Rat miR-142 is located in the first exon of the alternatively spliced transcript Q9JIR0-2. The orthologous alternative transcripts in human and mouse lacks the 5' exon, placing human and mouse miR-142 upstream of the BZRAP1 transcript.