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Table 2 MiDAS and RP alternative splicing detection.

From: Dissecting an alternative splicing analysis workflow for GeneChip®Exon 1.0 ST Affymetrix arrays

  Splicing set Splicing set Splicing set
  128.32 vs 512 32.2 vs 128 2.0 vs 32
  TP
(Sensitivity) 		FP
(1-Specificity) 		TP
(Sensitivity) 		FP
(1-Specificity) 		TP
(Sensitivity) 		FP
(1-Specificity)
MiDAS 119
(0.68) 		2416
(0.03) 		176
(0.91) 		2319
(0.03) 		138
(0.84) 		2338
(0.03)
RPI 174
(1.00) 		12941
(0.18) 		193
(1.00) 		11883
(0.17) 		164
(1.00) 		9989
(0.14)
MiDAS & RPI intersection 119
(0.68) 		436
(0.006) 		176
(0.91) 		424
(0.006) 		138
(0.84) 		375
(0.005)
  1. RPI is the Rank Product calculated using the intensity signals without SI calculation. Statistical analyses done using MiDAS or RPI, calculated using intensity signals, at p-value ≤ 0.05 are contaminated by a significant number of FPs due to the multiple test problem. The intersection of the results using the two methods significantly reduces the number of FPs.
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BMC Genomics

ISSN: 1471-2164

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