Table 2 Hubs and clustered nodes in the luminal ER+ network.
Hub | knode | Cnode | Differentially expressed neighbours | Physical interaction content | Transcriptional interaction content |
|---|---|---|---|---|---|
ESR1* | 27 | 0.020 | 3 | 53% | 47% |
PTN* | 19 | 0.012 | 6 | 95% | 5% |
TGFB1* | 17 | 0.000 | 0 | 47% | 53% |
HIST1H4H* | 16 | 0.000 | 0 | 100% | 0% |
HIST1H4I* | 16 | 0.000 | 0 | 100% | 0% |
GADD45G* | 13 | 0.051 | 2 | 88% | 12% |
EFEMP2* | 10 | 0.022 | 1 | 100% | 0% |
LNX1* | 10 | 0.000 | 0 | 100% | 0% |
AREG* | 9 | 0.000 | 0 | 44% | 56% |
CAV1* | 9 | 0.000 | 0 | 78% | 22% |
EGFR | 9 | 0.056 | 6 | 92% | 8% |
CRELD1* | 8 | 0.000 | 1 | 100% | 0% |
KRT18* | 8 | 0.036 | 1 | 89% | 11% |
PGR* | 8 | 0.143 | 1 | 63% | 37% |
SP1 | 8 | 0.036 | 6 | 0% | 100% |
EPS15* | 7 | 0.000 | 0 | 100% | 0% |
ERBB3* | 7 | 0.143 | 2 | 100% | 0% |
FGG* | 7 | 0.238 | 1 | 100% | 0% |
PCDHA4* | 7 | 0.000 | 0 | 100% | 0% |
UBQLN4 | 7 | 0.048 | 3 | 100% | 0% |
FGB* | 6 | 0.333 | 1 | 100% | 0% |
ATXN1 | 5 | 0.000 | 1 | 100% | 0% |
CD82* | 5 | 0.200 | 1 | 100% | 0% |
CEBPB | 5 | 0.000 | 1 | 20% | 80% |
COL8A1* | 5 | 0.100 | 1 | 100% | 0% |
EGR1 | 5 | 0.000 | 1 | 0% | 100% |
ERBB2 | 5 | 0.200 | 3 | 100% | 0% |
MBP* | 5 | 0.000 | 0 | 100% | 0% |
MLLT4* | 5 | 0.000 | 2 | 100% | 0% |
SMAD2 | 5 | 0.000 | 2 | 100% | 0% |
TP53 | 5 | 0.000 | 2 | 80% | 20% |