Table 3 Summary of modules from luminal networks
Module | Constituent hubs | Function | Ref. | Inferred module function |
|---|---|---|---|---|
Luminal ER - | Â | Â | Â | Â |
TLR | CD14 | Component of LPS receptor | [38] | Passive immune |
| Â | LY96 | Component of LPS receptor | [38] | response |
| Â | TLR4 | Component of LPS receptor | [38] | Â |
KIT/KRT | CD82 | Tetraspanin | [86] | Kinase signalling |
| Â | ERBB3 | ERBB family tyrosine kinase | [51] | pathways and |
| Â | GRB7 | Signalling adaptor protein | [87] | cellular structural |
| Â | KIT | Receptor tyrosine kinase | [88] | integrity |
| Â | KRT8 | Cytoskeletal component | [89] | Â |
| Â | KRT18 | Cytoskeletal component | [89] | Â |
| Â | LYN | Src family kinase | [90] | Â |
| Â | MUC1 | Mucin family cell surface protein | [91] | Â |
| Â | TEC | Non-receptor tyrosine kinase | [92] | Â |
TNF/FAS | BCL2 | Anti-apoptotic protein | [93] | Inflammatory |
| Â | BIK | Pro-apoptotic protein | [94] | response and cell |
| Â | BNIPL | Putative pro-apoptotic protein | [95] | death |
| Â | CCL2 | Inflammatory chemokine | [96] | Â |
| Â | CCL5 | Inflammatory chemokine | [96] | Â |
| Â | FAS | Prototype death receptor | [97] | Â |
| Â | RPS6KA5 | Serine/threonine kinase; controls transcriptional response to TNF | [98] | Â |
| Â | TNF | Pro-inflammatory cytokine | [97] | Â |
Luminal ER + | Â | Â | Â | Â |
ESR | CRELD1 | Cell adhesion molecule | [99] | Multifunctional |
| Â | ESR1 | Transcriptional regulator | [56] | Â |
| Â | GADD45G | DNA damage response | [100] | Â |
| Â | GIPC2 | Mediate cross-talk between cell signalling pathways | [101] | Â |
| Â | KRT19 | Cytoskeletal component | [89] | Â |
| Â | MYCBP | Interacts with Myc and A-kinase anchoring proteins | [102] | Â |
| Â | PGR | Transcriptional regulator | [39] | Â |
| Â | PTN | Activation of stromal fibroblasts and stimulation of angiogenesis | [103] | Â |
| Â | STC2 | Secreted glycoprotein with possible autocrine or paracrine function | [104] | Â |
| Â | WFDC2 | Secreted anti-microbial protein | [105] | Â |
ERBB3 | CD82 | Tetraspanin | [86] | Signal transduction |
| Â | ERBB3 | ERBB family tyrosine kinase | [51] | Â |
| Â | GRB7 | Signalling adaptor protein | [87] | Â |
MLLT4 | EPHB6 | Cell-cell interactions/adhesion | [35] | Cell adhesion |
| Â | MLLT4 | Cell adhesion | [106] | Â |
| Â | NRXN4 | Cell-cell interactions/adhesion | [107] | Â |
COL8A1 | COL8A1 | Extracellular matrix protein | [108] | Generation of |
| Â | EFEMP2 | Extracellular matrix protein | [109] | extracellular matrix |
KRT | KRT8 | Cytoskeletal component | [89] | Cellular structural |
| Â | KRT18 | Cytoskeletal component | [89] | integrity |
FGG | FGB | Extracellular matrix protein | [110] | Generation of |
| Â | FGG | Extracellular matrix protein | [110] | extracellular matrix |