Figure 10

Phylogenetic relationships of class A SLRPs (ECM2 and ECM2-like sequences), inferred from the multiple sequence alignment of LRR domains from a reduced set of SLRP sequences (see Methods). The tree has been rooted using the SLRP1 sequences from the two Ciona species as outgroup. Sequences group into three main clusters: ECM2, ECMX (ECM2-like protein from the X chromosome), and ECMZ (ECM2-like predicted protein upstream of the DCN gene in fish genomes). Clade probability values higher than 60% are indicated as in Figure 6. The scale bar represents amino acid substitutions per site.