Figure 3

Multiple sequence alignment of LRRCE motifs from a selected set of SLRP sequences from the UniProt non-redundant set. Names for the sequences are those of their corresponding Swiss-Prot or TrEMBL entries. Members of the different classes are shown with their names in green (class I), blue (class II), red (class III) or black (ECM2 and similar proteins). Two sequences from early SLRPs in urochordates (Ciona intestinalis and Ciona savigny) are also included with their name in magenta (see text). The boxes on the top indicate the two consecutive repeats LRR1 and LRR2 that contain the LRRCE motif. The ear itself is included in the first repeat. Residue conservation colour scheme: conserved cysteines in red; conserved residues in yellow; partially conserved residues in green; conserved prolines in cyan; polar residues in conserved hydrophobic sites in magenta; potential sites of N-linked glycosylation in blue.