LTβR-responsive genes can be allocated into distinct categories. (A) Venn-diagram of significantly (p < 0.05) regulated genes. (B) Schematic depiction of gene expression patterns. The four main categories in (A) can be segregated into further subcategories, depending on whether their genes were upregulated or downregulated. The arrows in the plots show the direction of gene expression changes from non-induced (0 h) to the 10 h induced state in response to LTβR stimulation. The first arrow describes gene expression behavior in wild-type, the second in relA-/-, and the third in relB-/- cells. Horizontal arrows indicate lack of change or statistically insignificant change in gene expression. Arrows pointing upwards or downwards indicate significant positive or negative regulation, respectively.