Skip to main content

Table 1 S. agalactiae genes that are differentially regulated in the mtaR mutant.

From: Global transcriptional profiling reveals Streptococcus agalactiae genes controlled by the MtaR transcription factor

Locus (gene) Function/annotation/homology P value Fold change
Transport and binding proteins
SAN_1753 (metP) ABC transporter, permease 4.4 × 10-6 -2.43
SAN_1754 (metN) ABC transporter, ATP-binding 5.8 × 10-7 -2.43
SAN_1756 (metQ) ABC transporter, substrate-binding 3.5 × 10-11 -5.30
SAN_0595 (artP) ABC transporter, permease 2.5 × 10-7 -2.35
SAN_0596 (artQ) ABC transporter, ATP-binding 9.7 × 10-6 -2.44
Protein fate: degradation of proteins, peptides, and glycopeptides
SAN_1755 (pdsM) Peptidase, M20/M25/M40 family 2.1 × 10-9 -3.72
SAN_2186 (cspA) Serine protease 2.3 × 10-7 -3.20
SAN_1255 Streptokinase-like 1.4 × 10-5 -2.65
Amino acid biosynthesis
SAN_0156 (argG) Argininosuccinate synthase 8.6 × 10-5 -2.60
SAN_0157 (argH) Argininosuccinate lyase 8.7 × 10-6 -2.91
Energy metabolism
SAN_0597 (manB) Phosphomannomutase or Phosphoglucomutase 4.1 × 10-5 -2.04
Hypothetical conserved
SAN_0933   8.3 × 10-4 +2.47
  1. The differentially-regulated genes are grouped into functional categories, based on experimental evidence, protein database searches, and genome annotation. Each GBS COH1 gene [14] is indicated by its Comprehensive Microbial Resources locus number (SAN number) available on the J. Craig Venter Institute website http://www.jcvi.org/cms/research/projects/cmr/ and gene symbol, when applicable. Fold changes in gene expression (mtaR mutant relative to wild-type) and Bayesian P values were derived using Cyber-T [38] analysis of data from three independent biological replicates. Criteria for inclusion in this table were the following: Bayesian P value < 0.001, greater than two-fold change, and confirmation of differential expression by qPCR (Table 2).