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Table 1 Correlation between gene expression and cell viability

From: Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression

Accession Number

Gene Name

LPS (μg/ml)

Pearson Correlation Coefficient (r)

   

Control (PBS)

1% H2O2

2% H2O2

3% H2O2

Down Regulated

Adhesion

      

   NM_001797

cadherin 11, type 2, OB-cadherin (osteoblast) (CDH11)

5

0.7715

0.9635

0.9903

0.9993

Anti-Oxidant

   NM_001512

glutathione S-transferase A4 (GSTA4)

1

0.6140

0.8818

0.9360

0.9669

   NM_020998

macrophage-stimulating protein (MST1)

1

0.6693

0.9135

0.9589

0.9827

   NM_005400

protein kinase C, epsilon (PRKCE)

5

0.6189

0.8847

0.9382

0.9684

   NM_004624

vasoactive intestinal peptide receptor 1 (VIPR1)

5

0.7329

0.9462

0.9804

0.9953

   NM_001915

cytochrome b-561 (CYB561)

5

0.7711

0.9633

0.9902

0.9992

Antibacterial Factors

   NM_020993

B-cell CLL/lymphoma 7A (BCL7A)

1

0.8045

0.9765

0.9963

0.9999

   NM_001735

sapiens complement component 5 (C5)

1

0.5590

0.8478

0.9100

0.9473

   NM_000565

interleukin 6 receptor (IL6R)

1

0.6850

0.9220

0.9648

0.9865

Apoptosis

   NM_000435

notch homolog 3 (Drosophila) (NOTCH3),

1

0.7489

0.9536

0.9848

0.9973

   NM_001618

poly (ADP-ribose) polymerase family, member 1 (PARP1),

1

0.6838

0.9214

0.9643

0.9862

   NM_021136

reticulon 1 (RTN1)

1

0.6122

0.8807

0.9352

0.9663

   NM_000041

apolipoprotein E (APOE)

5

0.7164

0.9381

0.9754

0.9927

   NM_001964

early growth response 1 (EGR1)

5

0.7975

0.9739

0.9952

1.0000

Brain Function

   NM_000027

aspartylglucosaminidase (AGA)

1

0.5997

0.8732

0.9295

0.9621

   NM_000441

solute carrier family 26, member 4 (SLC26A4)

5

0.7566

0.9571

0.9868

0.9981

   NM_004283

RAB3D, member RAS oncogene family (RAB3D)

5

0.8235

0.9830

0.9986

0.9988

   NM_003045

solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 (SLC7A1)

5

0.6901

0.9247

0.9666

0.9876

Cancer Marker

   NM_016730

folate receptor 1 (adult) (FOLR1)

1

0.6441

0.8994

0.9489

0.9760

   NM_005635

synovial sarcoma, X breakpoint 1 (SSX1)

1

0.7612

0.9591

0.9879

0.9985

Cell Cycle Regulation

   NM_005982

SIX homeobox 1 (SIX1)

5

0.6397

0.8969

0.9471

0.9748

   NM_005994

T-box 2 (TBX2)

5

0.6035

0.8755

0.9312

0.9634

Cytoskeletal Constitution and Rearrangement

   NM_001621

aryl hydrocarbon receptor (AHR)

1

0.6673

0.9124

0.9582

0.9822

   NM_000269

non-metastatic cells 1, protein (NM23A) expressed in (NME1)

1

0.5921

0.8685

0.9260

0.9595

   NM_003289

tropomyosin 2 (beta) (TPM2)

1

0.7030

0.9314

0.9710

0.9903

   NM_015873

villin-like (VILL)

1

0.5310

0.8296

0.8956

0.9361

   NM_003023

SH3-domain binding protein 2 (SH3BP2)

5

0.7448

0.9517

0.9837

0.9969

Extra Cellular Matrix-Degrading Proteases

   NM_007038

ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) (ADAMTS5)

1

0.6070

0.8776

0.9328

0.9646

Growth Factor and Related Protein Factors

   NM_018127

elaC homolog 2 (E. coli) (ELAC2)

1

0.6819

0.9203

0.9636

0.9858

   NM_003506

frizzled homolog 6 (Drosophila) (FZD6),

1

0.7105

0.9352

0.9735

0.9917

   NM_018344

solute carrier family 29 (nucleoside transporters), member 3 (SLC29A3)

1

0.6177

0.8840

0.9376

0.9680

   NM_021724

nuclear receptor subfamily 1, group D, member 1 (NR1D1)

1

0.6802

0.9194

0.9630

0.9854

   NM_001012

ribosomal protein S8 (RPS8)

1

0.6111

0.8801

0.9347

0.9659

   NM_003087

synuclein, gamma (breast cancer-specific protein 1) (SNCG)

1

0.7776

0.9660

0.9916

0.9996

   NM_015906

tripartite motif-containing 33 (TRIM33),

1

0.7008

0.9303

0.9703

0.9898

   NM_000222

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT)

1

0.6613

0.9091

0.9558

0.9807

   Y12863

growth factor FIGF

5

0.7831

0.9683

0.9927

0.9998

   NM_002086

growth factor receptor-bound protein 2 (GRB2)

1

0.6311

0.8919

0.9434

0.9722

   M35410

insulin-like growth factor binding protein 2 (IGFBP2)

1

0.6801

0.9194

0.9630

0.9854

   NM_001050

somatostatin receptor 2 (SSTR2)

1

0.9252

0.9996

0.9871

0.9658

   NM_016135

ets variant gene 7 (TEL2 oncogene) (ETV7)

5

0.6810

0.9198

0.9633

0.9856

   NM_006732

FBJ murine osteosarcoma viral oncogene homolog B (FOSB)

5

0.6889

0.9240

0.9662

0.9873

   NM_022963

fibroblast growth factor receptor 4 (FGFR4)

5

0.6720

0.9150

0.9600

0.9834

   NM_002957

retinoid × receptor, alpha (RXRA)

5

0.9264

0.9995

0.9866

0.9650

   NM_004630

splicing factor 1 (SF1)

5

0.8712

0.9955

0.9993

0.9904

   NM_005252

v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS)

5

0.8257

0.9837

0.9988

0.9986

Hemostasis

   NM_000624

peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 (SERPINA5)

1

0.6092

0.8790

0.9339

0.9653

Inflammation and Immunity

   NM_000963

cyclooxygenase-2 (COX2)

1

0.5186

0.8213

0.8890

0.9308

Transfer of Cargo Between Intracellular Membrane Organelles

   NM_016577

RAB6B, member RAS oncogene family (RAB6B)

1

0.7002

0.9299

0.9701

0.9897

Up Regulated

Cancer Marker

   NM_005814

glycoprotein A33 (transmembrane) (GPA33)

1

-0.9658

-0.9878

-0.9589

-0.9251

Cell Junction

   NM_001943

desmoglein 2 (DSG2)

1

-0.6663

-0.9119

-0.9578

-0.9820

Cytoskeletal Constitution and Rearrangement

   NM_002613

3-phosphoinositide dependent protein kinase-1 (PDPK1)

1

-0.5869

-0.8653

-0.9235

-0.9577

Gene Transcription

   NM_006180

neurotrophic tyrosine kinase receptor, type 2 (NTRK2)

1

-0.6822

-0.9205

-0.9637

-0.9858

   NM_013275

nasopharyngeal carcinoma susceptibility protein; lz16/ankyrin repeat domain 11 (ANKRD11)

1

-0.7789

-0.9666

-0.9918

-0.9997

  1. *Genes with a Pearson's product-moment correlation coefficient (r2) > 0.85 are listed. Those with coefficient r > 0.988 (α < 0.05) are in bold face.
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BMC Genomics

ISSN: 1471-2164

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