From: Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation
Feature | Source | Buffering gene pair – average | Buffering gene pair – count | Non-buffering gene pair – average | Non-buffering gene pair – count | t-score |
---|---|---|---|---|---|---|
Across genes | Â | Â | Â | Â | Â | Â |
mRNA abundance (molecules/cell) | [67] | 4.948 | 91 | 0.906 | 14 | 4.04* |
Protein abundance (molecules/cell) | [67] | 35040 | 29 | 2116 | 4 | 2.84 |
Molecular weight (Da) | [66] | 66299.9 | 99 | 91885.0 | 16 | -2.33 |
Codon Adaptation Index | [66] | 0.232 | 99 | 0.134 | 16 | 4.97* |
Codon Bias Index | [66] | 0.187 | 99 | 0.051 | 16 | 5.18* |
Protein production rate (s -1 ) | [68] | 0.632 | 90 | 0.056 | 12 | 3.45* |
Proteins produced per mRNA | [68] | 5.733 | 85 | 1.388 | 11 | 4.07* |
Transcription rate (s -1 ) | [68] | 0.109 | 85 | 0.040 | 11 | 2.87 |
Protein half-life (min) | [69] | 108.5 | 74 | 177.1 | 13 | -0.50 |
dN/dS | [70] | 0.056 | 56 | 0.113 | 8 | -1.95 |
No. orthologs in 14 organisms | [32] | 8.1 | 94 | 5.8 | 15 | 1.52 |
No. protein-protein interactions | [71] | 15.2 | 84 | 4.3 | 14 | 4.50* |
Between genes | Â | Â | Â | Â | Â | Â |
Sequence similarity (%) | BLAST output | 54.3 | 50 | 32.5 | 8 | 4.91* |
Shortest path – Functional network | [31] | 1.27 | 48 | 1.63 | 8 | -1.26 |
Vector similarity – Functional interactions | [31] | 0.15 | 23 | 0.04 | 7 | 2.04 |
Vector similarity – Physical interactions | [30] | 0.13 | 25 | 0.03 | 8 | 2.01 |
Vector similarity – Genetic interactions | See methods | 0.01 | 26 | 0.07 | 7 | -1.49 |
Vector similarity – KO phenotypes | [63] | 0.17 | 10 | 0.11 | 2 | 0.27 |
Worm two-gene families (subset) | Â | Â | Â | Â | Â | Â |
Length (nt) | [66] | 1556 | 254 | 1359 | 32 | 1.10 |
Codon Adaptation Index | [64] | 0.396 | 254 | 0.326 | 32 | 2.46 |
dN (Ka) | Analysis by [33] | 0.34 | Â | 0.50 | Â | Â |