Skip to main content

Table 3 miRNAs and their targets

From: Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease

a: miRNAs and their previously reported targets (from Argonaute database). miRNAs and their corresponding targets are both differentially regulated during PKD.
miRNA Target Genes Pathways
miR-128 ABCB9, BTG1, DSCR1, RASD1 ABC transporters General
miR-136 GRN, PPP1R9B  
miR-147 HOXA1, PTGFRN  
miR-148 EGR3, SCN3A  
miR-181b IGF1R, NKX6-1 Adherens junction, Maturity onset diabetes of the, Focal adhesion, **Long term depression
miR-196a ABCB9, CPB2, IRS1, MAPK10 ABC transporters General, Complement and coagulation cas, Adipocytokine signaling pathwa, Insulin signaling pathway, Type II diabetes mellitus, Fc epsilon RI signaling pathwa, Focal adhesion, **GnRH signaling pathway, **MAPK signaling pathway, Toll like receptor signaling p, Wnt signaling pathway
miR-203 SARA1  
miR-20 BTG1, SARA1, YWHAB Cell cycle
miR-21 TPM1  
mir-216 GNAZ **Long term depression
miR-217 RHOA Adherens junction, Axon guidance, Focal adhesion, Leukocyte transendothelial mig, Regulation of actin cytoskelet, TGF beta signaling pathway, T cell receptor signaling path, Tight junction, Wnt signaling pathway
miR-31 ATP2B2, DNM1L, EGR3, PPP1R9B, YWHAB **Calcium signaling pathway, Cell cycle
miR-7 SLC23A2  
miR-7b HRH3, NCDN, SLC23A2 **Neuroactive ligand receptor in
b: miRNAs and their targets (from TargetScan and miRanda). miRNAs and their corresponding targets are both differentially regulated during PKD.
miRNA Target Genes Pathways
miR-128 ABCB9, BTG2, CACNB2, CNR1, COL3A1, GLRA2, IRS1, NEK6, PDE7B, PTPN5, SV2A, SYT4, YWHAB, NR5A2, NTRK3 ABC transporters General, **MAPK signaling pathway, **Neuroactive ligand receptor in, **Cell Communication, **ECM receptor interaction, Focal adhesion, Adipocytokine signaling pathwa, Insulin signaling pathway, Type II diabetes mellitus, Purine metabolism, Cell cycle, Maturity onset diabetes of the
miR-136 KCNH7  
miR-148 OTX1, YWHAB Cell cycle
miR-181b ADAMTS1, ATP2B2, CACNB2, CDH13, CNR1, DUSP6, EGR3, EPHA7, GRIK2, GRM5, GRM7, HOXA1, MMP14 **Calcium signaling pathway, **MAPK signaling pathway, **Neuroactive ligand receptor in, Axon guidance, Gap junction, **Long term depression, Long term potentiation, **GnRH signaling pathway
miR-196a ABCB9, COL3A1, EPHA7, GAS7, OTX1 ABC transporters General, **Cell Communication, **ECM receptor interaction, Focal adhesion, Axon guidance
miR-203 TGFB3 Cell cycle, **MAPK signaling pathway, TGF beta signaling pathway
miR-21 BTG2  
miR-217 CLU, FN1, GRIK2, KCNH5, NR4A2, RAP1B **Cell Communication, **ECM receptor interaction, Focal adhesion, Regulation of actin cytoskelet, **Neuroactive ligand receptor in, Leukocyte transendothelial mig, Long term potentiation, **MAPK signaling pathway
miR-302b* ATP2B2 **Calcium signaling pathway
miR-302c ATP2B2, CNR1, SNF1LK **Calcium signaling pathway, **Neuroactive ligand receptor in
miR-302c* ATP2B2, SNF1LK **Calcium signaling pathway
miR-30a-3p CCKBR, COLEC12, EPHA7, GRM7, JUN, KCNAB1, LIN7A, MAMDC1, PRRX1 **Calcium signaling pathway, **Neuroactive ligand receptor in, Axon guidance, B cell receptor signaling path, Focal adhesion, **GnRH signaling pathway, **MAPK signaling pathway, T cell receptor signaling path, Toll like receptor signaling p, Wnt signaling pathway
miR-346 GRM7, LTBP2 **Neuroactive ligand receptor in
miR-372 ATP2B2, NR4A2, SNF1LK, RET, SLC11A2 **Calcium signaling pathway
miR-448 COLEC12, DNM3, GRIK2, IGF1R, IL12B, KCNH7, KCNIP4, SCN3A, SCN5A **Neuroactive ligand receptor in, Adherens junction, Focal adhesion, **Long term depression, **Cytokine cytokine receptor int, **Jak STAT signaling pathway, Toll like receptor signaling p, **Type I diabetes mellitus
miR-34b BTG2, CALCR, DLL1, MYRIP **Neuroactive ligand receptor in, Notch signaling pathway
miR-380-3p BCL2L1 Amyotrophic lateral sclerosis, Apoptosis, **Jak STAT signaling pathway, Neurodegenerative Disorders
miR-7b EGR3  
  1. **Significantly overrepresented pathways from ORA