Table 2 Chimp protein kinases with significant difference compared to their closest human homologues.
Chimp protein kinase and kinase subfamily assignment | Nearest human protein kinase and kinase subfamily assignment | Sequence identity between Chimp sequence & human sequence | Remarks |
|---|---|---|---|
ENSPTRP00000038601(CAMK1) | ENSP00000359161 (CAMK1) | 86.07% | The N-terminal part of the Chimp sequence containing glycine motif in the kinase domain is missing as compared to the human kinase domain |
ENSPTRP00000044216 (AGC_other) | ENSP00000302750 (AGC_other) | 75.57% | The human sequence has DMPK_coil domain which is lacking in its closest Chimp sequence. However, domain organization given below is present in other Chimp kinases. Human sequence: Pkinase, Pkinase_C, DMPK_coil, C1, PH, CNH Chimp sequence: Pkinase, Pkinase_C, C1, PH, CNH |
ENSPTRP00000000076 (AGC2) | ENSP00000367830 (AGC2) | 87.5% | Human sequence has C1 domain which is lacking in the Chimp sequence Human sequence: PB1, C1, Pkinase, Pkinase_C Chimp sequence: PB1, Pkinase, Pkinase_C |
ENSPTRP00000037507 (RAF) | ENSP00000290277 (RAF) | 67.47% | Human sequence has C1 domain is which is lacking in the Chimp sequence Human sequence: RBD, C1, Pkinase Chimp sequence: RBD, Pkinase |
ENSPTRP00000011569 (CAMK1) | ENSP00000270202 (AGC3) | 99.06% | The Chimp kinase which belongs to CAMK1 is having PH domain N-terminal to the kinase domain which is very unusual as PH domain is not notmally seen seen with CAMK1. Moreover, the domain organization of these two protein kinases are different. Human protein kinase has Pkinase_C domain in the C-terminal which is lacking in the Chimp protein kinase. Human sequence: PH, Pkinase, Pkinase_C Chimp sequence: PH, Pkinase |
ENSPTRP00000022133 (Unclassified) | ENSP00000311684 (CAMK1) | 95.2% | The close Chimp homologue of this human sequence is PKLNK Human sequence: I-set X 6, fn3, I-set X 2, Pkinase, I-set, fn3, Pkinase Chimp sequence: I-set X 6, fn3, I-set X 2, Pkinase, I-set, fn3, PKLNK |
ENSPTRP00000027141 | ENSP00000371341 (PTK8) | 59% | The close Chimp homologue of this human sequence is PKLNK Human sequence: Pkinase, SH3, GTPase binding domain Chimp sequence: PKLNK, SH3, GTPase binding domain |
ENSPTRP00000027139 | ENSP00000323216 (PTK8) | 70.6% | The close Chimp homologue of this human sequence is PKLNK Human sequence: Pkinase, SH3, GTPase binding domain Chimp sequence: Pkinase, SH3, GTPase binding domain |
ENSPTRP00000027136 | ENSP00000329425 (PTK8) | 57.1% | The close Chimp homologue of this human sequence is PKLNK Human sequence: Pkinase, SH3, GTPase binding domain, UBA Chimp sequence: PKLNK, SH3, GTPase binding domain, UBA |
ENSPTRP00000001150 (CK1) | ENSP00000361275 (Polo) | 65.5% | The Chimp kinase is closely related to CK1 but it has POLO box domain C-terminal to the kinase domain |
ENSPTRP00000020259 | ENSP00000306717 | 94.6% | The Human kinase has Ldl receptor A domain in the N-terminus which is lacking in the Chimp homologue Human sequence: Ldl receptor A, MAM, Pkinase Chimp sequence: MAM, Pkinase |
ENSPTRP00000019171 | ENSP00000291270 | 94.2% | The Chimp kinase sequence has putative transmembrane region in the C-terminus which is absent in the Human kinase. Human sequence: Pkinase, Pkinase_C, DMPK_coil Chimp sequence: Pkinase, Pkinase_C, DMPK_coil, TM |