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Table 2 KEGG pathway enrichment for human switch-like genes.

From: Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality

 

Human bimodal genes

Mouse bimodal genes

KEGG Pathway

Genes Observed

Genes Expected

Ration of Enrichment

P-values

Genes Observed

Genes Expected

Ration of Enrichment

P-values

Tight junction

39

17.09

2.28

2.87E-07

30

14.60

2.05

4.52E-05

Cell adhesion molecules (CAMs)

36

16.81

2.14

4.31E-06

23

16.92

1.36

7.17E-02

Regulation of actin cytoskeleton

51

27.54

1.85

6.10E-06

27

25.38

1.06

3.95E-01

Focal adhesion

50

26.84

1.86

6.22E-06

43

23.89

1.80

4.77E-05

Calcium signaling pathway

44

23.31

1.89

1.54E-05

25

20.90

1.20

1.91E-01

Citrate cycle (TCA cycle)

11

3.53

3.12

2.85E-04

6

3.98

1.51

1.96E-01

Glycolysis/Gluconeogenesis

18

7.91

2.28

4.64E-04

14

7.47

1.88

1.16E-02

PPAR signaling pathway

19

8.62

2.21

5.10E-04

17

9.46

1.80

9.09E-03

Long-term potentiation

20

9.32

2.15

5.47E-04

15

8.13

1.85

1.08E-02

Leukocyte transendothelial migration

28

15.11

1.85

7.12E-04

20

14.10

1.42

6.15E-02

Carbon fixation

9

2.97

3.03

1.29E-03

7

2.99

2.34

2.00E-02

Adherens junction

20

10.17

1.97

1.81E-03

13

10.12

1.28

2.02E-01

Gap junction

24

13.14

1.83

2.03E-03

16

10.95

1.46

7.02E-02

Melanogenesis

23

12.57

1.83

2.44E-03

14

12.94

1.08

4.19E-01

Type I diabetes mellitus

13

5.65

2.30

2.49E-03

11

7.80

1.41

1.44E-01

Alanine and aspartate metabolism

10

3.96

2.53

3.57E-03

6

3.65

1.64

1.44E-01

Neurodegenerative Diseases

12

5.23

2.30

3.67E-03

5

4.98

1.00

5.72E-01

MAPK signaling pathway

50

34.61

1.44

4.14E-03

36

31.36

1.15

2.04E-01

Reductive carboxylate cycle (CO2 fixation)

5

1.27

3.93

4.29E-03

2

1.66

1.21

5.13E-01

Endometrial cancer

14

7.06

1.98

7.76E-03

11

6.80

1.62

6.59E-02

Pyruvate metabolism

11

5.09

2.16

8.75E-03

7

4.81

1.45

1.94E-01

ECM-receptor interaction

20

11.58

1.73

8.98E-03

25

10.45

2.39

1.00E-05

Long-term depression

18

10.45

1.72

1.31E-02

17

9.12

1.86

6.16E-03

Cell Communication

25

16.10

1.55

1.53E-02

34

15.43

2.20

2.47E-06

Insulin signaling pathway

27

18.36

1.47

2.38E-02

26

15.93

1.63

6.19E-03

Fructose and mannose metabolism

7

4.94

1.42

2.17E-01

12

5.31

2.26

3.63E-03

Cysteine metabolism

2

2.12

0.94

6.47E-01

4

1.00

4.02

8.53E-03

  1. KEGG pathways enrichment was computed using the set of human bimodal genes as well as previously identified bimodal genes in mouse. Pathways enriched with p ≤ 0.01 in both bimodal human genes and the set of bimodal mouse genes are shown in bold. Italicized values do not meet the p ≤ 0.01 significance threshold.
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BMC Genomics

ISSN: 1471-2164

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