Table 5 Gene Ontology terms enriched for bimodal genes with "high" or "low" expression within brain, heart, and skeletal muscle tissues in human and mouse.
From: Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality
| Â | Â | Brain | Heart | Skeletal Muscle | |||
|---|---|---|---|---|---|---|---|
| Â | Â | Human | Mouse | Human | Mouse | Human | Mouse |
CC | actin cytoskeleton | Â | Â | high | Â | high | high |
| Â | axon | high | high | low | low | low | low |
| Â | basal lamina | Â | low | Â | Â | Â | Â |
| Â | basement membrane | Â | low | Â | high | Â | high |
| Â | cell junction | high | high | Â | low | low | low |
| Â | cell projection | high | high | Â | Â | Â | Â |
| Â | collagen | low | low | Â | high | high | high |
| Â | cytoplasm | high | Â | high | Â | high | Â |
| Â | cytoskeleton | Â | low | high | high | high | high |
| Â | growth cone | high | high | low | Â | Â | Â |
| Â | I band | Â | Â | Â | Â | Â | high |
| Â | integral to plasma membrane | Â | Â | Â | Â | low | Â |
| Â | membrane | Â | high | Â | Â | low | Â |
| Â | membrane fraction | Â | Â | Â | low | Â | low |
| Â | muscle myosin complex | low | Â | Â | Â | high | Â |
| Â | myosin complex | low | low | Â | Â | Â | high |
| Â | plasma membrane | Â | Â | Â | Â | low | Â |
| Â | postsynaptic membrane | high | high | low | low | Â | low |
| Â | proteinaceous extracellular matrix | low | low | high | high | Â | high |
| Â | sarcolemma | Â | low | Â | high | Â | high |
| Â | sarcoplasmic reticulum | low | low | high | Â | high | high |
| Â | striated muscle thick filament | low | Â | Â | Â | high | Â |
| Â | synapse | high | high | low | low | low | low |
| Â | synaptic vesicle membrane | Â | Â | Â | Â | Â | low |
| Â | troponin complex | Â | low | Â | Â | high | high |
| Â | Z disc | low | low | high | high | high | high |
BP | antigen processing and presentation of peptide antigen via MHC class I | Â | low | high | Â | Â | high |
| Â | cell adhesion | Â | low | high | high | Â | high |
| Â | cell differentiation | Â | high | Â | Â | Â | Â |
| Â | central nervous system development | high | Â | low | Â | Â | Â |
| Â | cytoskeleton organization and biogenesis | Â | Â | Â | Â | Â | high |
| Â | glycogen metabolic process | low | Â | Â | high | high | Â |
| Â | glycolysis | Â | Â | high | high | high | Â |
| Â | ion transport | high | high | Â | low | Â | low |
| Â | muscle contraction | low | low | high | Â | high | high |
| Â | muscle development | low | Â | Â | Â | high | high |
| Â | nervous system development | high | high | low | Â | low | Â |
| Â | neuron differentiation | Â | high | low | Â | Â | Â |
| Â | neuron migration | Â | high | Â | Â | Â | Â |
| Â | regulation of heart contraction | Â | Â | high | high | Â | Â |
| Â | regulation of muscle contraction | Â | low | Â | Â | Â | high |
| Â | regulation of striated muscle contraction | Â | Â | Â | Â | high | Â |
| Â | regulation of the force of heart contraction | Â | Â | high | high | high | Â |
| Â | sensory perception of sound | Â | high | high | Â | Â | Â |
| Â | striated muscle contraction | low | low | high | Â | high | Â |
| Â | synaptic transmission | high | high | low | low | low | low |
| Â | transport | high | high | Â | low | Â | low |
| Â | tricarboxylic acid cycle | Â | Â | high | high | high | high |
MF | actin binding | Â | Â | high | Â | high | high |
| Â | calcium ion binding | Â | Â | high | Â | high | high |
| Â | extracellular matrix structural constituent | low | low | high | high | Â | high |
| Â | GTPase activity | high | Â | Â | Â | Â | Â |
| Â | ion channel activity | Â | high | Â | low | Â | low |
| Â | microfilament motor activity | Â | Â | Â | Â | high | Â |
| Â | NAD binding | Â | Â | Â | Â | high | Â |
| Â | protein binding | low | Â | Â | Â | Â | Â |
| Â | structural constituent of muscle | low | low | high | Â | high | Â |
| Â | structural molecule activity | Â | low | high | Â | Â | Â |