Figure 3
From: An evolutionary and structural characterization of mammalian protein complex organization
Complexes and selection. dN/dS distribution of genes associated with A) all human proteins and B) proteins in the human complex data. D) The mean dN/dS ratio for human-mouse orthologs is plotted against the number of unique proteins in the complex. Complexes with more unique proteins have a significantly smaller mean dN/dS ratios than those with less unique proteins (t-test: P < 3.1 × 10-7). F) The dN/dS ratio for human-mouse orthologs is plotted against the number of complexes they participate in. Proteins participating in more complexes have significantly lower dN/dS ratios than those with less complex participation (t-test: P < 7.4 × 10-9). C, E) Both trends are rarely observed for model 1 random complexes.