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Figure 4 | BMC Genomics

Figure 4

From: An evolutionary and structural characterization of mammalian protein complex organization

Figure 4

Coverage by binary domain and protein interactions. Coverage is indicated by values in the Venn diagrams. Example: A) Protein content coverage. 71% of the proteins in our complexes with 3 or more unique proteins can be explained by either domain-domain or binary protein interactions. The full protein content of 29% of these complexes can be explained by either interaction-type. 14% of binary ppi can be explained by predicted domain-domain interactions. B) Interaction coverage. 5% of IntAct binary interactions could be explained from predicted domain-domain interactions. 77% of solved protein-protein contacts in our complexes of known structure with 3 or more unique proteins can be explained by either domain-domain or binary protein interactions. All solved contacts in 52% of these complexes can likewise be explained by these interactions.

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