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Table 2 Differentially expressed genes.

From: Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni

dbEST Ac No

Mean

Sourcea

BlastX matchb

Organism

Acc No

Expect

EW996975*

-5.261

SSH

Ornithine decarboxylase 1

Danio rerio

NP_571876.1

3E-16

EW997424

-5.124

SSH

Unknown

   

EW997539

-4.996

SSH

Unknown

   

CK656700

-4.845

ORESTES

Multidrug resistance transporter-like protein

Pseudopleuronectes americanus

AAL15148.1

2E-34

CO870193*

-4.816

ORESTES

Unknown

   

CK149228*

-4.806

ORESTES

Titin

Homo sapiens

CAA49245.1

3E-17

EW997032*

-4.801

SSH

Unknown

   

CK656739

-4.772

ORESTES

Unknown2

   

EW997027

-4.698

SSH

Unknown

   

EW997530

-4.698

SSH

Unknown

   

CK656724

-4.696

ORESTES

Unknown

   

EW997444

-4.643

SSH

MBCTL1

Monosiga brevicollis

AAP78680.1

5E-04

CO870221

-4.597

ORESTES

Unknown1

   

CK656720*

-4.594

ORESTES

Unknown

   

EW997542

-4.544

SSH

Unknown

   

CK656728

-4.539

ORESTES

Crooked neck-like 1 protein

Mus musculus

NP_080096.1

1E-105

EW997099

-4.488

SSH

Unknown9

   

EW996832

-4.472

SSH

NADH ubiquinone oxidoreductase

Caenorhabditiselegans

NP_496376.1

1E-30

EW997050

-4.459

SSH

Bystin

H. sapiens

AAH50645.1

2E-34

EW996838

-4.417

SSH

Unknown

   

EW996831

-4.407

SSH

Unknown

   

EW997370

-4.382

SSH

Unknown

   

CO870223

-4.361

ORESTES

Unknown1

   

EW997028

-4.316

SSH

Unknown

   

EW997117

-4.306

SSH

Unknown

   

EW997432

-4.303

SSH

Unknown

   

CK656726

-4.299

ORESTES

Cytoplasmic intermediate filament protein

Ascaris lumbricoides

CAA60047.1

3E-27

EW997187

-4.287

SSH

Unknown

   

EW997456

-4.264

SSH

Unknown

   

EW996835

-4.248

SSH

Unknown

   

EW997566

-4.247

SSH

Unknown

   

CK656741

-4.225

ORESTES

Ubiquitin

Suberites domuncula

CAA76578.1

9E-26

EW996808

-4.224

SSH

NHL domain containing protein

C. elegans

NP_499028.1

4E-10

EW996834

-4.201

SSH

Unknown

   

CO870200

-4.195

ORESTES

Unknown1

   

EW997451

-4.193

SSH

Unknown

   

EW997446

-4.158

SSH

Importin 7; RAN-binding protein 7

D. rerio

NP_006382.1

9E-40

EW997144

-4.122

SSH

Unknown

   

EW996812

-4.120

SSH

Unknown

   

EW997049

-4.109

SSH

Unknown

   

EW997528

-4.103

SSH

Myosin light chain kinase smooth

Bos taurus

Q28824

7E-09

EW997428

-4.094

SSH

Hypothetical protein

Deinococcus radiodurans

NP_294693.1

2E-15

EW997118

-4.068

SSH

Unknown8

   

CK656734

-4.056

ORESTES

Unknown1

   

CK149216

-4.053

ORESTES

Unknown

   

EW997092

-4.050

SSH

Unknown8

   

EW997556

-4.035

SSH

Unknown

   

EW997531

-4.021

SSH

Unknown

   

CK656703

-3.992

ORESTES

Sqstm1 protein

M. musculus

AAH06019.1

0.0003

EW997407

-3.976

SSH

Unknown

   

EW997035

-3.971

SSH

Unknown

   

EW997077

-3.961

SSH

Unknown

   

CK656698

-3.954

ORESTES

Unknown

   

EW997078

-3.932

SSH

Unknown

 

.

.

CK656711

-3.932

ORESTES

ADP/ATP carrier2

Neocallimastix patriciarum

AAL79525.1

1E-30

EW997555

-3.920

SSH

Elongation factor-27

Rattus norvegicus

CAC81931.1

3E-32

EW996976

-3.915

SSH

Ornithine decarboxylase

C. elegans

NP_504752.1

2E-25

EW997411

-3.892

SSH

Lactate/malate dehydrogenase

C. elegans

NP_872154.1

5E-09

EW997017

-3.890

SSH

Fumarylacetoacetate hydrolase-related protein

A. thaliana

NP_172669.2

2E-37

EW997501

-3.881

SSH

Unknown

   

EW996972

-3.875

SSH

Unknown6

   

EW997045

-3.864

SSH

ATF6

H. sapiens

BAA34722.1

0.0004

CK656733

-3.830

ORESTES

Ubiquitin-conjugating enzyme E2D 2

D. rerio

AAH48896.1

2E-18

EW997087

-3.827

SSH

Unknown

   

EW996855

-3.824

SSH

Unknown

   

EW997194

-3.813

SSH

Unknown9

   

CK656713

-3.797

ORESTES

Unknown

   

CO870211

-3.796

ORESTES

Unknown

   

EW997015

-3.785

SSH

Unknown

   

EW997129

-3.758

SSH

Unknown

   

EW997449

-3.757

SSH

Unknown5

   

EW997533

-3.754

SSH

Unknown

   

EW997418

-3.740

SSH

Hypothetical protein

Aspergillus nidulans

EAA64844.1

7E-11

EW996827

-3.736

SSH

Serine 2 transmembrane protease

M. musculus

NP_056590.1

4E-25

CK656737

-3.734

ORESTES

70 kDa heat shock protein3

Artemia franciscana

AAL27404.1

5E-59

CK656706

-3.723

ORESTES

M-phase phosphoprotein 1

H. sapiens

NP_057279.1

4E-4

CO870188

-3.720

ORESTES

Cathepsin L-like protease precursor

A. franciscana

AAD39513.1

3E-5

EW997548

-3.683

SSH

Gnat-family acetyltransferase

Bordetella parapertussis

NP_883664.1

6E-29

EW997412

-3.677

SSH

Cytochrome b

Macaca tonkeana

AAK26394.1

7E-51

EW997170

-3.669

SSH

Unknown6

   

EW996822

-3.593

SSH

Unknown

   

EW997067

-3.569

SSH

Elongation factor 27

Entamoeba histolytica

Q06193

8E-6

EW997053

-3.558

SSH

Elongation factor 1-alpha

Coccidioides immitis

Q96WZ1

1E-12

CK656707

-3.550

ORESTES

Heat shock protein 703

Ambystoma mexicanum

AAK31583.1

1E-67

CK656701

-3.541

ORESTES

Unknown

   

EW997447

-3.511

SSH

Unknown

   

EW997408

-3.502

SSH

Unknown

   

EW996986

-3.501

SSH

Ribosomal protein Rps2

Cricetulus griseus

AAQ94085.1

6E-08

EW997107

-3.483

SSH

Unknown

   

EW997105

-3.478

SSH

Streptavidin V2 precursor

Streptomyces violaceus

Q53533

7E-5

EW997127

-3.472

SSH

Cytochrome oxidase subunit I

Platynectes decempunctatus

AAN11289.1

1E-40

EW996813

-3.472

SSH

Unknown

   

EW996825

-3.462

SSH

Unknown5

   

EW996824

-3.461

SSH

Adenosylhomocysteinase 3

R. norvegicus

XP_231564.1

5E-43

CO870190

-3.460

ORESTES

Glutamyl-prolyl-tRNA synthetase

D. melanogaster

NP_524471.2

4E-56

EW997004

-3.458

SSH

Unknown

   

EW997180

-3.435

SSH

Unknown1

   

EW997569

-3.430

SSH

Oligomycin sensitivity conferring protein

D. melanogaster

CAA67980.1

1E-23

CK656696

-3.346

ORESTES

Histidyl-tRNA synthetase

M musculus

Q61035

5E-84

EW997520

-3.337

SSH

Copine-related

A. thaliana

NP_564907.1

3E-70

EW997051

-3.324

SSH

Cytochrome Oxidase subunit Vb

C. elegans

NP_492601.1

2E-12

EW997435

-3.315

SSH

Unknown

   

CO870229

-3.300

ORESTES

Unknown

   

EW997131

-3.210

SSH

Tyrosyl-tRNA synthetase

H. sapiens

AAB39406.1

8E-26

EW997037

-3.151

SSH

Cytochrome c1 precursor

A. thaliana

NP_198897.1

5E-44

DY523263*^

3.502

SSH

Unknown

   

EW996837*

3.710

SSH

Unknown

   

DY523267*^

3.938

SSH

Unknown4

   

EW997405

4.542

SSH

Unknown4

   

EW996814*

5.308

SSH

Unknown

   
  1. Genes identified as differentially expressed between resistant and susceptible snail lines, ranked in order of mean (across the 4 replicate arrays) fold difference in expression, based on normalized mean intensity ratios. Negative fold difference values indicate resistant-associated clones.
  2. aSource indicates whether the clone was from a suppression subtractive hybridization (SSH) library or open reading frame EST (ORESTES) library.
  3. bThe name, organism, accession number and e-value given for the best match with GenBANK using BLASTX.
  4. * Chosen for qPCR
  5. ^ also confirmed from SSH experiment
  6. 1–9 clusters of overlapping sequences
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BMC Genomics

ISSN: 1471-2164

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