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Table 1 Signature gene sets for OTSCC

From: Transcriptomic dissection of tongue squamous cell carcinoma

  Symbol Probe ID Gene Name Location
Upregulated genes in OTSCC
  MMP1 204475_at matrix metalloproteinase 1 11q22.3
  MMP10 205680_at matrix metalloproteinase 10 11q22.3
  MMP3 205828_at matrix metalloproteinase 3 11q22.3
  MMP12 204580_at matrix metallopeptidase 12 11q22.3
  PTHLH 211756_at parathyroid hormone-like hormone 12p12.1-p11.2
  INHBA 210511_s_at inhibin, beta A 7p15-p13
  LAMC2 202267_at laminin, gamma 2 1q25-q31
  IL8 202859_x_at interleukin 8 4q13-q21
  KRT17 205157_s_at keratin 17 17q12-q21
  COL1A2 202404_s_at collagen, type I, alpha 2 7q22.1
  IFI6 204415_at interferon, alpha-inducible protein 6 1p35
  ISG15 205483_s_at ISG15 ubiquitin-like modifier 1p36.33
  PLAU 205479_s_at plasminogen activator, urokinase 10q24
  GREM1 218468_s_at gremlin 1 15q13-q15
  MMP9 203936_s_at matrix metallopeptidase 9 20q11.2-q13.1
  IFI44 214453_s_at interferon-induced protein 44 1p31.1
  CXCL1 204470_at chemokine (C-X-C motif) ligand 1 4q21
Downregulated genes in OTSCC
  KRT4 213240_s_at keratin 4 12q12-q13
  MAL 204777_s_at mal, T-cell differentiation protein 2cen-q13
  CRNN 220090_at Cornulin 1q21
  SCEL 206884_s_at Sciellin 13q22
  CRISP3 207802_at cysteine-rich secretory protein 3 6p12.3
  SPINK5 205185_at serine protease inhibitor, Kazal type 5 5q32
  CLCA4 220026_at chloride channel, calcium activated, family member 4 1p31-p22
  ADH1B 209612_s_at 209613_s_at alcohol dehydrogenase IB (class I), beta polypeptide 4q21-q23
  P11 206605_at 26 serine protease 12q13.1
  TGM3 206004_at transglutaminase 3 20q11.2
  RHCG 219554_at Rhesus blood group, C glycoprotein 15q25
  PPP1R3C 204284_at protein phosphatase 1, regulatory (inhibitor) subunit 3C 10q23-q24
  CEACAM7 206199_at carcinoembryonic antigen-related cell adhesion molecule 7 19q13.2
  HPGD 203914_x_at hydroxyprostaglandin dehydrogenase 15-(NAD) 4q34-q35
  CFD 205382_s_at D component of complement (adipsin) 19p13.3
  ABCA8 204719_at ATP-binding cassette, sub-family A (ABC1), member 8 17q24
  CLU 222043_at Clusterin 8p21-p12
  CYP3A5 214235_at cytochrome P450, family 3, subfamily A, polypeptide 5 7q21.1
  1. * The complete lists of upregulated and downregulated transcripts in OTSCCs were presented in Supplement Table S1 and S2, respectively.