Table 3 Overrepresented GO categories compared to control within the allogeneic transplantation group. The top 10 significantly overrepresented GO categories on the third level (p < 0.05, Fisher's exact test, with Benjamini and Hochberg correction) related to biological process (BP), cellular component (CC) and molecular function (MF) in the set of genes down- or up-regulated after allogeneic transplantation (aTX) compared to control are shown in Table 3. The numbers indicate the quantity of genes corresponding with the GO-terms.
From: Activation of counter-regulatory mechanisms in a rat renal acute rejection model
aTX_down | |||
|---|---|---|---|
Category | Term | Count | p-value |
BP | nitrogen compound metabolism | 119 | 8,1E-11 |
BP | catabolism | 130 | 3,7E-6 |
BP | cellular metabolism | 864 | 3,9E-4 |
BP | transport | 408 | 5,1E-4 |
BP | establishment of localization | 459 | 1,4E-3 |
BP | excretion | 18 | 5,1E-3 |
CC | organelle inner membrane | 110 | 1,7E-25 |
CC | mitochondrial envelope | 116 | 1,1E-23 |
CC | organelle envelope | 128 | 1,9E-15 |
CC | cytoplasm | 695 | 5,8E-15 |
CC | organelle membrane | 165 | 9,3E-15 |
CC | mitochondrial lumen | 41 | 4,6E-7 |
CC | membrane fraction | 171 | 8,8E-7 |
MF | electron carrier activity | 45 | 7,6E-17 |
MF | oxidoreductase activity, acting on NADH or NADPH | 37 | 1,8E-12 |
MF | primary active transporter activity | 55 | 2,5E-8 |
MF | metal ion transporter activity | 39 | 4,3E-7 |
MF | oxidoreductase activity, acting on the CH-CH group of donors | 22 | 8,8E-6 |
MF | oxidoreductase activity, acting on CH-OH group of donors | 38 | 1,1E-4 |
MF | coenzyme binding | 21 | 2,0E-4 |
aTX_up | |||
BP | immune response | 283 | 1,7E-44 |
BP | defense response | 292 | 8,1E-43 |
BP | response to pest, pathogen or parasite | 180 | 6,4E-26 |
BP | response to other organism | 180 | 2,3E-24 |
BP | macromolecule metabolism | 797 | 1,4E-23 |
BP | cell activation | 78 | 2,7E-14 |
BP | cell death | 198 | 1,9E-13 |
BP | response to wounding | 141 | 1,8E-11 |
BP | primary metabolism | 1079 | 8,0E-9 |
BP | cell cycle | 171 | 2,2E-8 |
CC | ribonucleoprotein complex | 138 | 1,7E-22 |
CC | intracellular non-membrane-bound organelle | 318 | 3,9E-18 |
CC | nucleus | 581 | 3,0E-12 |
CC | ribosome | 81 | 1,2E-11 |
CC | cytosolic small ribosomal subunit (sensu Eukaryota) | 23 | 2,2E-8 |
CC | T cell receptor complex | 14 | 1,5E-6 |
CC | nuclear envelope | 44 | 2,0E-5 |
CC | intracellular organelle | 1000 | 2,3E-5 |
CC | spliceosome complex | 25 | 9,6E-5 |
CC | proteasome complex (sensu Eukaryota) | 25 | 1,5E-4 |
MF | RNA binding | 178 | 3,5E-31 |
MF | cytokine binding | 30 | 8,5E-4 |
MF | sugar binding | 36 | 6,8E-3 |
MF | translation factor activity, nucleic acid binding | 33 | 8,6E-3 |
MF | translation initiation factor activity | 22 | 1,3E-2 |
MF | protease activator activity | 10 | 4,3E-2 |